線虫glad-4/GDL1遺伝子のエピジェネティクスな発現調節機構の解明

Material type: 文書・図像類

Author: 原田, 真市ほか

Publisher: 金沢大学医薬保健研究域医学系

Publication date: 2022-06-13

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Note (General)：: Mutations in the glyoxalase gene, GLO1 which encode a methylglyoxal metabolizing enzyme, have been reported in some patients with schizophrenia. To un...

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Material Type: 文書・図像類
Title: 線虫glad-4/GDL1遺伝子のエピジェネティクスな発現調節機構の解明
Author/Editor: 原田, 真市
Harada, Shinichi
Author Heading: 原田, 真市
Harada, Shinichi
Publication, Distribution, etc.: 金沢大学医薬保健研究域医学系
Publication Date: 2022-06-13
Publication Date (W3CDTF): 2022-06-13
Alternative Title: Mechanisms of epigenetic regulation of glod-4/GLO1 gene in C. elegans
Periodical title: 令和3(2021)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2021 Fiscal Year Final Research Report
No. or year of volume/issue: 2019-04-01 - 2022-03-31
Volume: 2019-04-01 - 2022-03-31
Pages: 6p.-
Text Language Code: jpn
Subject Heading: Glyoxlase
Target Audience: 一般
Note (General): Mutations in the glyoxalase gene, GLO1 which encode a methylglyoxal metabolizing enzyme, have been reported in some patients with schizophrenia. To understand the transcriptional mechanisms of GLO1, we analyzed the transcriptional regulatory regions of the glad-4 gene, which encodes the human GLO1 gene homolog in the nematode C. elegans. As a result, multiple highly homologous regions were found in the upstream regulatory regions of both the GLO1 / glod-4 gene, but it was not possible to identify the binding activity of SKN-1/Nrf2, which is one of the transcription factor, that binds the ARE motif identified in the upstream region of GLO1 gene.In addition, we found the compound X, which is presumed to be involved in the life extension of the glod-4 mutant by using the screening of the drug library.
統合失調症患者の一部にはメチルグリオキサールの代謝酵素であるグリオキサラーゼ遺伝子GLO1の変異が報告されている。そこで、ヒトGLO1遺伝子と線虫C. elegansのグリオキシラーゼをコードするglod-4遺伝子の転写調節領域の解析を行なった。その結果、GLO1/glod-4遺伝子双方の発現調節領域に相同性の高い複数の領域が見つかったが、転写調節因子とされるSKN-1がglod-4遺伝子発現に関与するかは特定できなかった。また、線虫C. elegansの表現形の一つ、寿命を指標として薬剤ライブラリーのスクリーニングからglod-4変異体の寿命延長に関与すると推定される化合物Xを見つけた。
研究課題/領域番号:19K07842, 研究期間(年度):2019-04-01 - 2022-03-31
出典：研究課題「線虫glad-4/GDL1遺伝子のエピジェネティクスな発現調節機構の解明」課題番号19K07842（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K07842/19K07842seika/）を加工して作成
DOI: 10.24517/00057415
Source: https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=51112&item_no=1&attribute_id=26&file_no=1
https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=51112&item_no=1&attribute_id=26&file_no=1
Access Restrictions: 限定公開
Rights (production): CC BY-NC-ND
Related Material: https://kaken.nii.ac.jp/search/?qm=90272955
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K07842/
https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K07842/19K07842seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA