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- Material Type
- 文書・図像類
- Author/Editor
- 樋口, 公嗣
- Author Heading
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- Alternative Title
- Gene therapy for myocardial infarction by using lentivirus encoding kit ligand
- Text Language Code
- jpn
- Subject Heading
- Target Audience
- 一般
- Note (General)
- 2010-2011年度科学研究費助成事業(科学研究費補助金(若手研究(B)))研究成果報告書 課題番号：22790717 研究代表者：樋口公嗣 (鹿児島大学大学院医歯学総合研究科特任助教)Kit ligand（KL）のアイソフォームによる心筋梗塞後の治療効果について検討する目的で本研究を行った。In vitroの実験でKLを感染させた細胞を用いて可溶型・膜型KLの発現を確認した。マウス心筋梗塞モデルで内因性KL-1、KL-2とc-kitの心臓での発現を評価し、内因性のKL-2は心筋梗塞後に低下しており、KL-2レンチウイルスによる治療がマウス心筋梗塞後の予後を改善させる可能性が示唆された。心筋梗塞モデルマウスに対し遺伝子治療を行い評価予定であったが、ウイルス調製が遅れたため、今後継続して行う予定である。The purpose of this study is to evaluate the effect of kit ligand(KL) isoform against myocardial infarction(MI). The KL expression in transduced cells was confirmed by western blotting and flow cytometry. Endogenous KL-1, KL-2 and c-kit expression in infarcted mouse hearts were evaluated. We found that KL-2 expression in mouse hearts was diminished after MI. Therefor gene therapy using lentivirus encoding KL-2 may improve the prognosis after MI. We were supposed to finish in vivo experiments in this year, however we have difficulties in making large scale virus. We will continue to do in vivo experiments.