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- Material Type
- 文書・図像類
- Author/Editor
- 赤崎, 雄一
- Author Heading
- Publication, Distribution, etc.
- Alternative Title
- Novel therapy on sarcopenia by targeting Akt signaling
- Text Language Code
- jpn
- Target Audience
- 一般
- Note (General)
- 2012-2013年度科学研究費助成事業（研究活動スタート支援）研究成果報告書 課題番号：24890178 研究代表者：赤崎雄一（鹿児島大学・医歯（薬）学総合研究科・助教）老化による骨格筋減少症（サルコペニア）に対して、骨格筋特異的にAkt1シグナルを活性化することは、加齢に伴った骨格筋減少症を改善し、内臓脂肪・皮下脂肪を減少させ、脂肪肝を改善した。それにより、糖代謝異常を改善した。以上より、サルコペニアが加齢に伴う代謝異常の重要な因子であり、速筋の量を保持もしくは改善させることは、これらの代謝異常の発症を遅らすための有効な治療法になることが示唆された。Akt1-mediated increase in muscle mass led to reductions in fat mass and hepatic steatosis in older animals, and corrected age-associated impairments in glucose metabolism. These results indicate that the loss of lean muscle mass is a significant contributor to the development of age-related metabolic dysfunction and that interventions that preserve or restore fast/glycolytic muscle may delay the onset of metabolic disease.