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- Material Type
- 文書・図像類
- Author/Editor
- 佐藤, 強志
- Author Heading
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- Text Language Code
- jpn
- Target Audience
- 一般
- Note (General)
- 2008-2010年度科学研究費補助金(基盤研究(C))研究成果報告書 課題番号：20592206 研究代表者：佐藤強志 (鹿児島大学大学院医歯学総合研究科准教授)（１）動物モデルでの扁平上皮癌腫瘍組織における放射性医薬品輸送蛋白発現の免疫組織学的染色による検討では、輸送蛋白の細胞膜上発現が顕著に観察され、放射性医薬品の取り込みと汲み出しとの相関が明らかであった。（２）ピンホールコリメータを用いたリンパ節模型のシンチ画像撮像では、臨床を想定した条件下ではピンホール径は５mm以上必要であり、小さな径では計数値の不足による雑音の影響が無視できなかった。また、10mmのリンパ節サイズ模型における放射性医薬品の局在識別は５mmが限界であった。(1) Expression of transport proteins of nuclear agents on cell membrane was evaluated immunohistochemically by using animal models with squamous cell carcinoma. The expression of transport proteins was found distinctly on the tumor cell membrane and showed a clear correlation with the accumulation of nuclear agents in tumor cells. (2) Scintigraphic imaging of lymph node model was done with pinhole collimators of 5 mm and 7 mm in hole size and the spatial resolution was about 5 mm. This result showed a possibility that scintigraphic imaging with pinhole collimator could detect a micro metastasis in lymph nodes of over 10 mm in size.
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