新規脊髄損傷再生療法による損傷神経回路網再建メカニズムの解明

Material type: 文書・図像類

Author: 棈松, 昌彦

Publisher: 鹿児島大学

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Note (General)：: 2010-2011年度科学研究費助成事業(科学研究費補助金(若手研究(B)))研究成果報告書　課題番号：22791381　研究代表者：棈松昌彦 (鹿児島大学医学部・歯学部附属病院医員)重度脊髄損傷などの壊れた中枢神経回路網の再建は非常に難しく、根本的な治療法は未だに確立していない。我々は神経幹細胞と...

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Material Type: 文書・図像類
Title: 新規脊髄損傷再生療法による損傷神経回路網再建メカニズムの解明
Author/Editor: 棈松, 昌彦
Author Heading: 棈松, 昌彦
Publication, Distribution, etc.: 鹿児島大学
Alternative Title: Regenerative therapy for spinal cord injury and their mechanism for reconstruction
Text Language Code: jpn
Alias of Author: あべ松, 昌彦
Subject Heading: 脊椎脊髄病学
Target Audience: 一般
Note (General): 2010-2011年度科学研究費助成事業(科学研究費補助金(若手研究(B)))研究成果報告書　課題番号：22791381　研究代表者：棈松昌彦 (鹿児島大学医学部・歯学部附属病院医員)
重度脊髄損傷などの壊れた中枢神経回路網の再建は非常に難しく、根本的な治療法は未だに確立していない。我々は神経幹細胞と抗てんかん薬を併用して効率よく神経細胞をつくり、重度脊髄損傷マウスが歩行可能になる治療法を開発するとともに、このときに働く新たな治癒メカニズムを明らかにしたので報告する。
Neural stem cells (NSCs) possess the ability to self-renew and to differentiate into the three major cell types found in the central nervous system (CNS). Recent studies have shown that epigenetic gene regulation events such as DNA methylation and histone modification play important roles in regulating NSC fate specification. In this context, we have previously shown that the histone deacetylase inhibitor valproic acid (VPA) enhances neuronal differentiation of NSCs. Perhaps because these patterns of NSC differentiation are exquisitely controlled during normal embryonic development, restoration of damaged neural networks in the injured adult CNS is severely limited. Here, using a mouse model of spinal cord injury(SCI), we examined the effectiveness of NSC transplantation and differentiation control by VPA administration.
Format (IMT): application/pdf
Source: 22791381seika.pdf （fulltext）
https://ir.kagoshima-u.ac.jp/record/2509/files/22791381seika.pdf
Access Restrictions: 限定公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ