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- Material Type
- 文書・図像類
- Author/Editor
- 中馬, 猛久
- Author Heading
- Publication, Distribution, etc.
- Alternative Title
- The mode of infection of anti-microbial resistant Salmonella and the treansmission of the determinants of the resistance.
- Text Language Code
- jpn
- Target Audience
- 一般
- Note (General)
- 2011-2013年度科学研究費助成事業（基盤研究（C））研究成果報告書 課題番号：23580426 研究代表者：中馬猛久（鹿児島大学・獣医学部・教授）南日本のブロイラーから分離されたサルモネラのうちアンピシリン、セフォタキシムの両剤に耐性を示したのは33株（35.5%）でblaTEM52、blaTEM20型ESBL産生株がそれぞれ22株、1株認められ、以前の報告と比較して著しく増加していた。IncP型のプラスミドはtetA、aadA1、sul1の3つの耐性遺伝子を保有し、3つの血清型から検出されたため、多剤耐性の拡大と大きく関わっていることが示された。調査したサルモネラにはプラスミドが広く存在し、異なる血清型間に共通のプラスミドが存在したことから、CTX耐性及び多剤耐性サルモネラの増加とプラスミドは大きく関わっていることが判明した。The study was conducted to determine the antimicrobial resistance and characterize the B-lactamase genes and the plasmids in S. Infantis isolates from broilers. In 93 (6.3%) isolates recovered, 33 (35.5%) isolates showed resistance to cefotaxime conferred by TEM-20, TEM-52 and CTX-M-25 ESBLs. In addition to ESC-resistance, eight (8.6%) isolates exhibited resistance to cefoxitin mediated by CMY-2 AmpC B-lactamase. Plasmid analysis revealed the blaTEM-20 and blaCMY2 genes were associated with IncP plasmids, blaTEM was -52 linked with a non-typable plasmid and blaCTX-M-25 was carried by an IncA/C plasmid. Resistance to streptomycin, sulfamethoxazole, and oxytetracycline encoded by the aadAl, sull, and tetA, respectively, was found in 86 (92.5%) isolates. These data indicate that S. Infantis isolates producing ESBLs and AmpC B-lactamase have spread among broiler farms in Japan. These data demonstrated the incidence of ESC-resistant S. Infantis carrying blaTEM-52 remarkably increased.