MLH1発現抑制とそれに伴うPMS2の発現低下が神経膠芽腫のTMZ耐性獲得に寄与する

Material type: 博士論文

Author: 新里, 能成

Publisher: Oncotarget

Publication date: 2013

Material Format: Digital

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Name of awarding university/degree: 鹿児島大学,博士(医学),Doctor of Philosophy in Medical Science

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Note (General)：: 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨Although there is a relationship between DNA repair deficiency and temozolomide (TMZ) resistance in glioblastoma (GB...

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Material Type: 博士論文
Title: MLH1発現抑制とそれに伴うPMS2の発現低下が神経膠芽腫のTMZ耐性獲得に寄与する
Author/Editor: 新里, 能成
Author Heading: 新里, 能成シンサト, ヨシナリ
Publication, Distribution, etc.: Oncotarget
Publication Date: 2013
Publication Date (W3CDTF): 2013
Alternative Title: Reduction of MLH1 and PMS2 confers temozolomide resistance and is associated with recurrence of glioblastoma
Periodical title: Oncotarget
No. or year of volume/issue: 4 12
Volume: 4
Issue: 12
Degree grantor/type: 鹿児島大学
Date Granted: 2014-03-18
Dissertation Number: 甲総研第270号
Degree Type: 博士(医学)
Doctor of Philosophy in Medical Science
Text Language Code: eng
Target Audience: 一般
Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨
Although there is a relationship between DNA repair deficiency and temozolomide (TMZ) resistance in glioblastoma (GBM), it remains unclear which molecule is associated with GBM recurrence. We isolated three TMZ-resistant human GBM cell lines and examined the expression of O6-methylguanine-DNA methyltransferase (MGMT) and mismatch repair (MMR) components. We used immunohistochemical analysis to compare MutL homolog 1 (MLH1), postmeiotic segregation increased 2 (PMS2) and MGMT expression in primary and recurrent GBM specimens obtained from GBM patients during TMZ treatment. We found a reduction in MLH1 expression and a subsequent reduction in PMS2 protein levels in TMZ-resistant cells. Furthermore, MLH1 or PMS2 knockdown confered TMZ resistance. In recurrent GBM tumours, the expression of MLH1 and PMS2 was reduced when compared to primary tumours. Yoshinari Shinsato, Tatsuhiko Furukawa, Shunji Yunoue, Hajime Yonezawa, Kentarou Minami, Yukihiko Nishizawa, Ryuji Ikeda, Kohichi Kawahara, Masatatsu Yamamoto, Hirofumi Hirano, Hiroshi Tokimura, and Kazunori Arita Reduction of MLH1 and PMS2 confers temozolomide resistance and is associated with recurrence of glioblastoma Oncotarget 4(12) 2013 doi: https://doi.org/10.18632/oncotarget.1302
Format (IMT): application/pdf
Source: Diss_新里_能成_ISK270_2013.pdf （fulltext）
https://ir.kagoshima-u.ac.jp/record/3109/files/Diss_%E6%96%B0%E9%87%8C_%E8%83%BD%E6%88%90_ISK270_2013.pdf
Access Restrictions: インターネット公開
Related Material (DOI): 10.18632/oncotarget.1302
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ