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Bibliographic Record
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- Material Type
- 文書・図像類
- Author/Editor
- 蓮井, 和久
- Author Heading
- Publication, Distribution, etc.
- Alternative Title
- Academic project of oncogenic factors in malignant tumors and the related diseases in northeast China
- Text Language Code
- jpn
- Target Audience
- 一般
- Note (General)
- 2007-2010年度科学研究費補助金(基盤研究(B))研究成果報告書 課題番号：19406007 研究代表者：蓮井和久 (鹿児島大学大学院医歯学総合研究科講師)この研究は、中国東北地方で多い鼻咽頭リンパ腫を検索し、エプスタイン・バールウイルス (EBV)関連NK/T細胞リンパ腫での腫瘍性EBV潜伏感染拡大、EBV非関連微小扁平上皮癌の併発、特異な壊死・自己貪食細胞死、発症前の外因による点突然変異を示唆する抗酸化ストレス性、特異な共生樹状細胞の存在を明らかにし、組織幹細胞形質による扁平上皮癌診断と自己貪食解析と酸化ストレス解析の免疫組織学的方法を確立した。This study examined many cases of nasopharyngeal lymphomas frequently seen in northeast China, elucidating neoplastic expansion of Epstein-Barr virus (EBV) latent infection, complication of minute EBV-not-associated squamous cell carcinoma in EBV-associated NK/T-cell lymphomas, peculiar necrosis of autophagic cell death, lymphoma cells’ antioxidant response suggesting point mutations induced by environmental factors before its occurrence, and peculiar symbiotic dendritic cells and developed immunohistochemical methods of malignant tumor diagnosis by detecting a nature of tissue stem cells, analysis for autophagy and its cell death, and analysis for oxidation in DNA.