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- Material Type
- 文書・図像類
- Author/Editor
- 瀬戸口, 啓夫
- Author Heading
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- Alternative Title
- Molecular target therapy for muscloskeletal sarcoma-initiating cells
- Text Language Code
- jpn
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- Target Audience
- 一般
- Note (General)
- 2009-2011年度科学研究費助成事業(科学研究費補助金(基盤研究(C)))研究成果報告書 課題番号：21591919 研究代表者：瀬戸口啓夫 (鹿児島大学大学院医歯学総合研究科特任准教授)横紋筋肉腫の治療を目指してヒト横紋筋肉腫細胞株から横紋筋肉腫細胞においてFibroblast growth factor receptor 3 (FGFR3)陽性細胞ががん幹細胞様の性質を持つRhabdomyosarcoma-initiating cells (RIC)であることを見いだし、解析を行った。FGFR3陽性RICの維持にはbFGFが必須でEGFはRICの増殖を誘導することを明らかとした。また骨軟部肉腫におけるHedgehogシグナルの腫瘍増殖・腫瘍転移における機能解析を行った結果、Hedgehogシグナルは骨肉腫・横紋筋肉腫の増殖を誘導しており、分子標的治療ターゲットとなることが示唆された。Rhabdomyosarcoma cell lines included small populations of fibroblast growth factor receptor 3 (FGFR3)-positive cells. FGFR3-positive KYM-1 and RD cells were more strongly tumourigenic than FGFR3-negative cells. Our findings suggest that rhabdomyosarcoma cell lines include a minor subpopulation of FGFR3-positive sarcoma-initiating cells, which can be maintained indefinitely in culture and which is crucial for their malignancy. In addition, We found that inhibition of Hedgehog pathway prevents osteosarcoma and rhabdomyosarcoma growth. Our findings suggest that inhibition of Hedgehog pathway may represent an effective therapeutic approach for patients with osteosarcoma and rhabdomyosarcoma.