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- Material Type
- 文書・図像類
- Author/Editor
- 白方, 良典
- Author Heading
- Publication, Distribution, etc.
- Alternative Title
- The development of biomimetic periodontal regenerative therapy by layered application of various growth factors and TCP-based materials
- Text Language Code
- jpn
- Target Audience
- 一般
- Note (General)
- 2010-2011年度科学研究費助成事業(科学研究費補助金(若手研究(B)))研究成果報告書 課題番号：22791931 研究代表者：白方良典 (鹿児島大学医学部・歯学部附属病院講師)イヌ骨内欠損においてエナメルマトリックス蛋白（EMD）,塩基性線維芽細胞増殖因子（bFGF）とβ三リン酸カルシウム（TCP）の歯周組織再生に及ぼす影響について比較検討を行った。外科的に作製したイヌ１壁性骨内欠損に対し、無作為にTCP単独、EMDとTCP併用（EMD/TCP）、bFGFとTCP併用（bFGF/TCP）および全て併用（EMD/bFGF/TCP）処置を行った。新生骨形成量は全群で有意差は認められなかった。EMD/bFGF/TCP群はTCP群やbFGF/TCP群より有意にセメント質形成量が多く、有意差は認めないもののEMD/TCP群より多かった。これらのことはEMD/bFGF/TCPの積層応用はセメント質再生に有効であることが示唆された。This study evaluated the effects of enamel matrix derivative (EMD) and/or basic fibroblast growth factor (bFGF) with β-tricalcium phosphate (β-TCP) on periodontal healing in intrabony defects in dogs. One-wall intrabony defects created in dogs were treated with β-TCP alone (TCP), EMD with β-TCP (EMD/TCP), bFGF with β-TCP (bFGF/TCP), and their combination (EMD/bFGF/TCP). The amount of new bone formation was not significant for any group. EMD/bFGF/TCP group induced significantly greater new cementum formation than TCP and bFGF/TCP groups, and formed, although not significantly, more new cementum than EMD/TCP group. These findings indicate that EMD/bFGF/TCP treatment is effective for cementum regeneration.