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- Material Type
- 文書・図像類
- Author/Editor
- 山元, 和哉
- Author Heading
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- Alternative Title
- Development of biomolecule separation system by hybrid coacervate using hydraulic pressure
- Text Language Code
- jpn
- Subject Heading
- Target Audience
- 一般
- Note (General)
- 2012-2013年度科学研究費助成事業（若手研究（B））研究成果報告書 課題番号：24700483 研究代表者：山元和哉（鹿児島大学・理工学研究科・助教）静水圧による高圧力条件下での刺激応答性ハイブリットコアセルベートの反応場への展開を検討した。まず種々の官能基をランダムに含んでいる高分子量体のアクリルアミド系共重合体を設計し、温度および圧力変化におけるコアセルベート滴の形成を評価した。次に、高圧力条件下でのコアセルベート滴におけるラジカル重合と生体分子分離システムについて検討した。コアセルベート滴にモデル生体分子としてフェリチンを添加した場合、複合エマルジョンは長時間、安定であった。さらに液-固界面におけるフェリチンの高分子修飾を検討した。We examined the development of stimuli-responsive hybrid coacervate as the reaction field under high pressure condition by hydraulic pressure. First, we designed the acrylamide-based copolymers with higher molecular weight randomly containing carboxyl or hydroxyl groups. Their stimuli-responsive behavior on comonomer composition and pH of the polymer solution was precisely investigated. The coacervate droplets were easily formed above a lower critical solution temperature. Furthermore, we studied the coacervate droplet formation under high pressure conditions. Next, we examined radical polymerization and biomolecule separation system with the coacervate droplet under high pressure. When we added the ferritin protein cages (ca. 12 nm) as model biomolecule to the coacervate droplets, the composite emulsions were stable for a long time. Furthermore, we examined the assembly behavior of ferritin on the liquid-liquid and liquid-solid interface.