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Bibliographic Record
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- Material Type
- 文書・図像類
- Author/Editor
- 上村, 修司
- Author Heading
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- Alternative Title
- The effect of human neutrophil peptides on intestinal inflammation as determined by proteomics approaches
- Text Language Code
- jpn
- Target Audience
- 一般
- Note (General)
- 2009-2010年度科学研究費補助金(若手研究(B))研究成果報告書 課題番号：21790672 研究代表者：上村修司 (鹿児島大学医学部・歯学部附属病院医員)Human neutrophil peptides (HNPs)1-3は、低濃度では腸管上皮細胞株に対し細胞増殖作用を示すが、高濃度の条件では細胞障害作用を示した。また､HNPs1-3は腸管上皮細胞からのinterleukin-8 (IL-8)、vascular endothelial growth factor (VEGF)とintercellular adhesion molecule-1 (ICAM-1)の発現を亢進させた。さらにHNPs1-3を投与したDSS誘発マウス腸炎モデルは、HNPs1-3非投与群と比較し、有意に体重や腸管長が減少し、高い組織学的大腸炎活動性を示した。これらの結果からHNPs1-3が、腸管上皮細胞に作用し炎症性サイトカインの産生を促進させ、大腸炎を悪化させている可能性が示唆された。Human neutrophil peptides (HNPs) 1-3 promoted proliferation of epithelial cell lines at low peptide concentrations; however, higher peptide concentrations inhibited cellular proliferation. And, treatment with HNPs resulted in the increase expression of interleukin-1 (IL-8), vascular endothelial growth factor (VEGF) and intercellular adhesion molecule-1 (ICAM-1) from epithelial cell lines. Additionally, after administration of HNPs to DSS-induced mouse IBD model, high histological colitis score, weight loss, and shortening of the large intestine were observed as compared to non-treated mice. These results suggest that HNPs increase the expression of proinflammatory cytokines in intestinal epithelial cells and exacerbates experimental colitis.