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- Material Type
- 文書・図像類
- Author/Editor
- 吉田, 輝
- Author Heading
- Publication, Distribution, etc.
- Alternative Title
- Temperature receptors in treatment of neurogenic bladder
- Text Language Code
- jpn
- Target Audience
- 一般
- Note (General)
- 2009-2011年度科学研究費助成事業(科学研究費補助金(基盤研究(C)))研究成果報告書 課題番号：21500479 研究代表者：吉田輝 (鹿児島大学大学院医歯学総合研究科助教)ラットの摘出排尿筋収縮への温熱の影響と排尿反射への温熱とラズベリーケトン膀胱内注入の影響を調べた。温熱は、摘出排尿筋の高濃度Kとカルバコールによる収縮反応を抑制し、静止張力と自発収縮の振幅を低下させた。カルバコール収縮の抑制には細胞内Ca動態の抑制が関与していた。また温熱により排尿反射の排尿閾値圧、排尿時膀胱内圧、基礎圧の低下傾向を認め、ラズベリーケトンの膀胱内注入は排尿反射に影響を及ぼさなかった。We investigated the effect of warming on detrusor smooth muscle contraction and the effect of warming and intravesical infusion of raspberry ketone on micturition reflex in rats. Warming inhibited high K and carbachol-induced contractions and reduced resting tension and amplitude of spontaneous contraction. Inhibition of carbachol–induced contraction was due to the inhibition of intracellular calcium mobilization. Warming tended to reduce pressure threshold for inducing micturition, micturition pressure and basal pressure. Intravesical infusion of raspberry ketone had no effect on micturition reflex.