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- Material Type
- 文書・図像類
- Author/Editor
- 濵田, 季之
- Author Heading
- Publication, Distribution, etc.
- Alternative Title
- Exploration of new antitoxic compounds neutralizing ciguatera fish poisoning from some southern medicinal plants
- Text Language Code
- jpn
- Subject Heading
- Target Audience
- 一般
- Note (General)
- 2009-2011年度科学研究費助成事業(科学研究費補助金(基盤研究(C)))研究成果報告書 課題番号：21550161 研究代表者：濱田季之 (鹿児島大学大学院理工学研究科(理学系)准教授)世界中で年間2万人以上の中毒患者を出すシガテラ毒中毒の治療法は、症状の一時的緩和を目的とした伝承植物の使用のみであり，化合物レベルでの治療薬は存在していない。我々は、これまでの報告で知られている３１種のシガテラ毒伝承植物のうち、５種類の植物から、CTX/BTXによるNaチャンネル開放の抑制活性を指標にして、数種のシガテラ毒解毒作用を示す伝承薬用植物からのシガテラ毒解毒物質を探索した。Ciguatera fish poisoning (CFP) is an ichthyosarcotoxism caused by the consumption of tropical and subtropical coral fish contaminated with toxic polyether compounds, ciguatoxins (CTXs) and maitotoxin (MTX). Garrec et al. have reported that the extracts of some southern medicinal plants, traditionally used to treat CFP, to prevent in vitro neurotoxicity produced by CTX or brevetoxin (BTX). Here, we studied new CFP antitoxic compounds isolated from verious southern medicinal plants by using in vitro neurotoxicity assay.