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Bibliographic Record
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- Material Type
- 文書・図像類
- Author/Editor
- 坂本, 泰二
- Author Heading
- Publication, Distribution, etc.
- Alternative Title
- Development of ultrasound and bubble-liposome-mediated drug delivery to ocular tissues
- Text Language Code
- jpn
- Target Audience
- 一般
- Note (General)
- 2009-2011年度科学研究費助成事業(科学研究費補助金(挑戦的萌芽研究))研究成果報告書 課題番号：21659400 研究代表者：坂本泰二 (鹿児島大学大学院医歯学総合研究科教授)超音波とバブルリポゾームを組み合わせて、眼組織に薬物・遺伝子送達する方法を開発した。Green fluorescence protein (GFP)遺伝子をバブルリポゾームに包埋して、眼表面・眼内に注入し、超音波を局所照射した所、結膜や網膜の意図した部に限局した遺伝子導入が可能であった。特に、ミュラー細胞への遺伝子導入が優れていた。適切なパワーで、照射部位の組織傷害を最小にすることが可能であった。超音波端子は心臓カテーテルで用いるものを改良したものが効果的であった。We developed a novel method to deliver genes or drugs to ocular tissues using ultrasound and bubble-liposome. GFP cDNA embedded in bubble-liposome was injected in the vitreous followed by irradiation of ultrasound. GFP was strongly expressed by retina where ultrasound was irradiated. Tissue damage was minimal. We also developed a new ultrasound probe for that.