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Bibliographic Record
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- Material Type
- 文書・図像類
- Author/Editor
- 於保, 孝彦長田, 恵美
- Publication, Distribution, etc.
- Alternative Title
- Interaction between salivary proteins and oral bacteria : determinants for bacterial adherence and aggregation
- Text Language Code
- jpn
- Target Audience
- 一般
- Note (General)
- 2011-2012年度科学研究費助成事業(科学研究費補助金(挑戦的萌芽研究)研究成果報告書 課題番号：23659987 研究代表者：於保孝彦(鹿児島大学・大学院医歯学総合研究科・教授)唾液タンパク質と口腔細菌との相互作用で起こる２つの現象（エナメル質への菌体付着と唾液中での菌体凝集）が生じる条件を調べ、口腔細菌のクリアランスを強く進める条件を明らかにすることを目指した。その結果、齲蝕細菌ストレプトコッカス ミュータンスのクリアランスを進めるには、菌体凝集を強く誘導するために唾液凝集素のSRCRP5領域を活用することが有効であることが示唆された。Bacterial aggregation in saliva is advantageous for oral health since bacteria are swallowed before adhering to oral tissues. The purpose of this study was to investigate mechanisms by which bacterial adherence to saliva-coated enamel surfaces or saliva-induced bacterial aggregation occur. The results indicate that SRCRP5 region in salivary agglutinin is useful for the clearance of Streptococcus mutans.