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- Material Type
- 文書・図像類
- Author/Editor
- 宇都, 浩文
- Author Heading
- Publication, Distribution, etc.
- Alternative Title
- Involvement of hypertension in nonalcoholic fatty liver disease via the kininogen fragment peptide
- Text Language Code
- jpn
- Target Audience
- 一般
- Note (General)
- 2011-2013年度科学研究費助成事業（基盤研究（C））研究成果報告書 課題番号：23590981 研究代表者：宇都浩文（鹿児島大学・医歯（薬）学総合研究科・講師）非アルコール性脂肪性肝疾患（NAFLD）は、高血圧などの生活習慣病と関連し、NAFLD患者血中から同定したキニノゲン断片は高血圧と関連することから、NAFLDの病態進展と高血圧やキニノゲン断片との関連を検討した。塩分感受性高血圧ラットにコリン欠乏アミノ酸置換食と高塩分食を投与すると、高血圧は脂肪肝の程度には影響せず、IL-10やHO-1の発現抑制を介して肝炎と肝線維化を促進した。一方、NAFLDではキニノゲン分解が亢進していたが、NAFLDにおいてキニノゲン断片濃度と高血圧との関連はなかった。以上のことから、高血圧はNAFLDの増悪因子であるが、その作用にキニノゲンは関連しないと考えられた。Nonalcoholic fatty liver disease (NAFLD) is associated with lifestyle-related diseases such as hypertension. In a previous study, we identified kininogen fragments, which are associated with hypertension, in the serum of patients with NAFLD. In this study, we examined the relationship between the pathological conditions of NAFLD and the presence of hypertension or kininogen fragments. Administration of a high-salt diet, in addition to a choline-deficient L amino-acid-defined diet, to salt-sensitive by pertensive rats revealed that hypertension aggravated hepatitis and liver fibrosis by suppressing the expression of HO-1 and IL-10, but did not affect the degree of fatty liver. On the other hand, kininogen degradation was promoted in NAFLD, but there was no association between hypertension and kininogen fragment concentration in NAFLD patients. Therefore, hypertension is an accelerating factor of NAFLD, but kininogen is not associated with the interaction between NAFLD and hypertension.