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Bibliographic Record
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- Material Type
- 文書・図像類
- Author/Editor
- 後藤, 正道
- Author Heading
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- Alternative Title
- Evaluation of peripheral nerve damage in Buruli ulcer (Mycobacterium ulcerans infection)
- Text Language Code
- jpn
- Subject Heading
- Target Audience
- 一般
- Note (General)
- 2008-2010年度科学研究費補助金(基盤研究(C))研究成果報告書 課題番号：20500325 研究代表者：後藤正道 (鹿児島大学大学院医歯学総合研究科研究員)ブルーリ潰瘍は、抗酸菌M. ulcerans感染による痛みのない皮膚潰瘍であるが、病変に痛みがない原因は不明であった。M. ulceransが産生する毒性脂質mycolactoneをマウス足底に注射すると、局所に知覚過敏の後に知覚鈍麻がおき、末梢神経にシュワン細胞の膨化と壊死が起こった。また、培養シュワン細胞にmycolactoneを投与すると、 シュワン細胞の壊死とアポトーシスが起こった。さらに、ヒトの治療前後の皮膚生検組織でも神経の変性所見を見出した。これらの研究結果から、ブルーリ潰瘍の無痛性はmycolactoneの細胞毒性に起因することが明らかになった。Deep and painless ulcers are formed in Buruli ulcer (Mycobacterium ulcerans infection). However, mechanism of painless nature was unknown. By the injection of toxic lipid mycolactone produced by M. ulcerans into murine footpads, initial hyperesthesia and subsequent hypoesthesia were observed. Histologically, Schwann cells showed swelling and necrosis. Cultured Schwann cells showed necrosis and apoptosis after the addition of mycolactone. Furthermore, nerve damage was observed in the skin biopsies of Buruli ulcer. These results indicate that nerve damage induced by mycolactone is responsible for the painless nature of this disease.