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Bibliographic Record
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- Material Type
- 文書・図像類
- Author/Editor
- 池田, 聡
- Author Heading
- Publication, Distribution, etc.
- Alternative Title
- Molecular biological study of Muscle metabolic marker on muscle strengthening and disuse weakness
- Text Language Code
- jpn
- Target Audience
- 一般
- Note (General)
- 2009-2011年度科学研究費助成事業(科学研究費補助金(基盤研究(B)))研究成果報告書 課題番号：21300201 研究代表者：池田聡 (鹿児島大学医学部・歯学部附属病院講師)リハビリテーション医療において、廃用性筋力低下、筋力増強は非常に重要であるが、分子生物学的視点から筋力増強をとらえ、解析した研究は近年まで殆んど見られなかった。そこで、筋力増強モデルを用い、筋関連の転写因子、成長因子・筋構成タンパクの遺伝子およびタンパク発現を解析するためリアルタイムRT-PCR法によりmRNA発現定量をおこなった。また、denervation model を用いてmyostatinの定量をおこなった。Muscle strengthening and disuse weakness are very important on rehabilitation medicine. However, there are little study about muscle strengthening from the view point of molecular biology. Then, we examined the gene expression of muscular transcription factors, muscular growth factor, muscle constriction protein by real time RT-PCR method. Besides, quantitative analysis of myostatin on denervation model were done.