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Bibliographic Record
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- Material Type
- 文書・図像類
- Author/Editor
- 藤木, 誠
- Author Heading
- 藤木, 誠 フジキ, マコト
- Publication, Distribution, etc.
- Alternative Title
- Cruciate injury model and cruciate regeneration with MSC by using of BPR system in micro-mini pig
- Text Language Code
- jpn
- Subject Heading
- Target Audience
- 一般
- Note (General)
- 2010-2011年度科学研究費助成事業(科学研究費補助金(挑戦的萌芽研究))研究成果報告書 課題番号：22658100 研究代表者：藤木誠 (鹿児島大学農学部准教授)マイクロミニピッグ（MMP）を用いて半月板損傷モデルの作製と自己の皮下脂肪組織由来間葉系細胞による組織再生についての研究を行った。皮下脂肪組織由来間葉系細胞による移植細胞塊の作製は可能であることが確認された。MMP半月板部分欠損モデルによる再生に関しては、移植細胞塊の性質が保てなかったことにより確認できなかった。関節切開を伴わない半月および骨軟骨欠損モデルについては、膝関節症モデルとしての有効性が示唆された。The tissue regeneration was researched by using micro mini-pig (MMP) with the mesenchymal system cell derived from subcutaneous adipose tissue for meniscus injury model. It was confirmed that the preparation of plug for transplantation with mesenchymal cells derived from subcutaneous fat is possible. However, it was not possible to confirm meniscus regeneration by being not able to maintain the nature of the transplant spheroid for partial deficit model of the MMP. In meniscus and osteochondral defect model without arthrotomy, the effectiveness of knee osteoarthritis as a model was suggested.