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Bibliographic Record
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- Material Type
- 文書・図像類
- Author/Editor
- 宮田, 健
- Author Heading
- 宮田, 健 ミヤタ, タケシ
- Publication, Distribution, etc.
- Alternative Title
- DNA macromolecule as a vaccine antigen scaffold for organization of the antigens into repetitively ordered arrays
- Text Language Code
- jpn
- Target Audience
- 一般
- Note (General)
- 2012-2013年度科学研究費助成事業（若手研究（B））研究成果報告書 課題番号：24790404 研究代表者：宮田健（鹿児島大学・農学部・助教）我々は、新規の技術としてDNAを足場にした抗原の高分子量化と反復整列化の技術基盤の構築に成功した。具体的にはDNA結合タンパク質（DBP）およびDNAの構造的規則性を利用し、DBP-マラリアワクチン抗原/DNA複合体を構築した。この複合体には抗原が効率よくDNAに結合することがわかった。さらに動物実験の結果、抗原単独や抗原の化学融合体よりも有意に高い抗体応答を示すことが分かり、本技術の有用性を示すことができた。We have developed a new technology to enhance immune responses by generating complex which composed DNA-binding protein fused vaccine antigen and DNA (DBP-Ag/DNA). In this system, DNA was used as scaffold material, not genetic information. Vaccine efficacy of the DBP-Ag/DNA complex was evaluated using an ookinete surface protein of Plasmodium vivax, Pvs25. The DBP-Ag/DNA complex immunized mice were conferred a high immune response compared to Pvs25 alone immunized group. This system may be a promising approach for development of subunit vaccines against malaria.