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- Material Type
- 文書・図像類
- Author/Editor
- 岡村, 浩昭
- Author Heading
- Publication, Distribution, etc.
- Text Language Code
- jpn
- Target Audience
- 一般
- Note (General)
- 2011-2013年度科学研究費助成事業（基盤研究（C））研究成果報告書 課題番号：23550160 研究代表者：岡村浩昭（鹿児島大学・理工学研究科・教授）両親媒性のアミノベンゼンチオール誘導体およびスルファニルアニリン誘導体を用いた、新しい金ナノ粒子の調製法を開発した。これらの分子はミセルを形成し、その内部で金イオンを還元し、金ナノ粒子を生成する。生じる粒子のサイズと安定性は、用いる化合物の構造によって制御可能であった。また、複数種類の化合物を固定化した金ナノ粒子の調整も可能であることを確認した。末端に糖を結合したスルファニルアニリン誘導体を用いて、糖を集積化したシュガーボール型金ナノ粒子を調製した。得られたナノ粒子は、糖結合性タンパク質レクチンと特異的かつ可逆的に相互作用しうることを確認した。また、4種類の生理活性糖類縁体の合成もおこなった。We have developped a new preparation method of gold nanoparticles (AuNps) using amphipathic alkylaminobenzenthiols and alkylsulfanylanilines as reductive stabilizers (RS) that reduce Au3+ to AuNps and spontaneously stabilize the resulting AuNps by coordination with their thiol or amino group. Since the reduction reaction proceeds inside of the micelles of RS, the shape and stability of the resulting AuNp were controlled by the structure of RS. By using a mixture of these compounds, the AuNps covered with different type of compounds can be prepared. The AuNps covered with sugar molecules were easily prepared with the sugar-derived RS. The resulting sugar-AuNps showed specific and reversible interaction with concanavalin A, a carbohydrate-binding protein. Asymetric synthesis of four biologically active sugar mimics has also been accomplished. We are planning to introduce them to the RS to give biologically active AuNps.
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- application/pdf