Search by Bookstore
Holdings of Libraries in Japan
This page shows libraries in Japan other than the National Diet Library that hold the material.
Please contact your local library for information on how to use materials or whether it is possible to request materials from the holding libraries.
other
Search by Bookstore
Bibliographic Record
You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.
- Material Type
- 文書・図像類
- Author/Editor
- 宮脇, 昭彦
- Author Heading
- Publication, Distribution, etc.
- Alternative Title
- Significance of glycolytic metabolism activities in oral pre-cancer lesions
- Text Language Code
- jpn
- Target Audience
- 一般
- Note (General)
- 2009-2011年度科学研究費助成事業(科学研究費補助金(基盤研究(C)))研究成果報告書 課題番号：21592532 研究代表者：宮脇昭彦 (鹿児島大学大学院医歯学総合研究科助教)口腔前癌病変の標本を用いて、HIF-1α, Glut-1, Glut-3, PDK1の免疫染色を行った。軽度上皮性異形成, 中等度上皮性異形成ではHIF1α, Glut3は染色されなかった。Glut1では有棘層の一部に染色される症例があった。PDK1は,軽度上皮性異形成では染色されず,中等度上皮性異形成から高度上皮性異形成で陽性率が上昇した。上皮性異形成の比較的早期の段階で解糖系に関わる酵素の発現を認め,高度上皮性異形成は解糖系代謝が亢進していることが示唆された。The correlation between the degree of dysplasia in oral pre-cancer lesion and immunohisitochemical staining of HIF-1α, Glut-1, Glut-3, PDK1 antibodies was evaluated using specimens of oral pre-cancer lesions. The mild to moderate epithelial dysplasia was not stained with HIF-1α and Glut-3 antibodies. The mild to moderate dysplasia was stained with Glut-1 in prickle layer slightly. On the other hand, immunohistochemical expression of PDK1 in moderate to severe epithelial dysplasia was found efficiently. These findings suggest that expression of enzymes involved in glycolytic metabolism was recognized in early stage of epithelial dysplasia, and that in severe dysplasia, glycolytic metabolism was increased.