肺動脈性肺高血圧症患者における肺MIBG取り込み低下

• Material Type: 博士論文
• Title: 肺動脈性肺高血圧症患者における肺MIBG取り込み低下
• Author/Editor: 肥後, 建樹郎
• Author Heading: 肥後, 建樹郎 ヒゴ, ケンジュロウ
• Publication, Distribution, etc.: International Heart Journal Association
• Publication Date: 2018
• Publication Date (W3CDTF): 2018
• Alternative Title: Impairment of iodine-123-metaiodobenzylguanidine (123I-MIBG) uptake in patients with pulmonary artery hypertension
• Periodical title: International Heart Journal
• No. or year of volume/issue: 59 1
• Volume: 59
• Issue: 1
• Pages: 112-119
• ISSN (Periodical Title): PISSN : 13492365
• Degree grantor/type: 鹿児島大学
• Date Granted: 2017-09-29
• Dissertation Number: 甲総研第429号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Text Language Code: eng
• Subject Heading: Pulmonary hypertension; 123I-MIBG scintigraphy; Endothelial dysfunction
• Target Audience: 一般
• Note (General): 博士論文全文, 最終試験結果の要旨, 論文審査の要旨, 博士論文要旨; According to recent studies, lung uptake of iodine-123-metaiodobenzylguanidine (123I-MIBG) is impaired in many lung diseases and low lung uptake of 123I-MIBG suggests endothelial dysfunction of the pulmonary artery.123I-MIBG scintigraphy in patients with pulmonary hypertension (PH) has not yet been clinically evaluated. We hypothesized that the lung uptake of 123I-MIBG is reduced in patients with PH and differs among PH subtypes. The purpose of the present study was to analyze the lung uptake of 123I-MIBG in patients with PH and compare it with the data obtained by echocardiography or right heart catheterization. 123I-MIBG scintigraphy was performed in 286 consecutive patients from 2003 to 2014. We enrolled 21 patients with PH and 8 control patients.The 21 patients with PH were categorized into those with pulmonary artery hypertension(PAH, n=12) and those with chronic thromboembolic pulmonary hypertension (CTEPH, n=9). The mean pulmonary artery pressure was not significantly different between patients with CTEPH and PAH (37.7 ± 6.8 versus 32.3 ± 5.3 mmHg respectively; P=0.054). There were no significant differences in any other hemodynamic parameters between the two groups.The lung uptake of 123I-MIBG in PAH patients (early image: 1.54 ± 0.18, delayed image: 1.41 ± 0.16) was significantly lower than that of CTEPH patients (early image: 2.17 ± 0.25,P<0.0001; delayed image: 1.99 ± 0.20, P=0.0001, adjusted for ageand World Health Organization classification) and controls(early image: 2.32 ± 0.27, P=0.0007; delayed image: 1.92 ± 0.19,P=0.0007). In conclusion, we found for the first time that the lung uptake of 123I-MIBG in patients with PAH is lower than that in patients with CTEPH and controls.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): © 2018 by the International Heart Journal Association
• Related Material: URI; https://www.jstage.jst.go.jp/browse/ihj/
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ

Table of Contents

Result_Higo_Kenjuro_isk429_2017 other

Comments_Higo_Kenjuro_isk429_2017 other

Diss_肥後_建樹郎_ISK429_2017 fulltext

Abstruct_肥後_建樹郎_4513810331_2017 abstract