新生児壊死性腸炎ラットモデルに対する大建中湯の予防効果

Material type: 博士論文

Author: 新山, 新

Publisher: Springer

Publication date: 2017-10

Material Format: Digital

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Name of awarding university/degree: 鹿児島大学,博士(医学),Doctor of Philosophy in Medical Science

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Note (General)：: 博士論文全文, 最終試験結果の要旨, 論文審査の要旨, 博士論文要旨Purpose: Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease of premature infants. Daikenchuto...

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Material Type: 博士論文
Title: 新生児壊死性腸炎ラットモデルに対する大建中湯の予防効果
Author/Editor: 新山, 新
Author Heading: 新山, 新シンヤマ, シン
Publication, Distribution, etc.: Springer
Publication Date: 2017-10
Publication Date (W3CDTF): 2017-10
Alternative Title: The novel preventive effect of Daikenchuto (TJ-100), a Japanese herbal drug, against neonatal necrotizing enterocolitis (NEC) model in rats.
Periodical title: Pediatric Surgery International
No. or year of volume/issue: 33 10
Volume: 33
Issue: 10
Pages: 1109-1114
Degree grantor/type: 鹿児島大学
Date Granted: 2017-12-22
Dissertation Number: 甲総研第442号
Degree Type: 博士(医学)
Doctor of Philosophy in Medical Science
Text Language Code: eng
Subject Heading: necrotizing enterocolitis
rat model
Daikenchuto
NEC grade
IL-6
Target Audience: 一般
Note (General): 博士論文全文, 最終試験結果の要旨, 論文審査の要旨, 博士論文要旨
Purpose: Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease of premature infants. Daikenchuto, a Japanese herbal drug has several effects on the digestive system, so we investigated its preventive effects in a rat model of NEC. Methods: NEC was induced in newborn rats via asphyxia (100% N2 for 90 s; every 4 h) + LPS (4 mg/kg/day [administered orally on Days 0 and 1]). The effects of Daikenchuto were evaluated in 4 groups (control: 0 g/kg/day, I: 0.3 g/kg/day, II: 0.6 g/kg/day, III: 1.0 g/kg/day). Daikenchuto was administered into the stomach through a microcatheter. The incidence and severity of NEC were pathologically assessed using the NEC grade in accordance with Dovorak’s previous report. Cell positivity for inflammatory cytokine (IL-6) was also evaluated. Results: Daikenchuto reduced the incidence of NEC in control, Groups I, II, and III to 68.7%, 30.0%, 30.7%, and 13.3%, respectively. High dose Daikenchuto significantly improved the incidence of NEC, and the rate of IL-6 positive cells in group III was significantly lower than in the control group (p=0.04). Conclusion: We evaluated the effect of Daikenchuto against NEC and found that it reduced the incidence rate of NEC due to a decrease in the IL-6 production.
Format (IMT): application/pdf
Source: Diss_Isk442_2017_Shin_Shinyama （fulltext）
https://ir.kagoshima-u.ac.jp/record/14048/files/Diss_Isk442_2017_Shin_Shinyama.pdf
Access Restrictions: インターネット公開
Related Material: The final publication is available at link.springer.com
https://link.springer.com/article/10.1007%2Fs00383-017-4145-9
Is Version Of (URI): URI
https://doi.org/10.1007/s00383-017-4145-9
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ