先端巨大症術後コントロール群における代謝パラメーターの変化

• Material Type: 博士論文
• Title: 先端巨大症術後コントロール群における代謝パラメーターの変化
• Author/Editor: 米永, 理法
• Author Heading: 米永, 理法 ヨネナガ, マサノリ
• Publication, Distribution, etc.: The Japan Neurosurgical Society
• Publication Date: 2018-04-15
• Publication Date (W3CDTF): 2018-04-15
• Alternative Title: Postoperative Changes in Metabolic Parameters of Patients with Surgically Controlled Acromegaly : Assessment of New Stringent Cure Criteria
• Periodical title: Neurologia medico-chirurgica
• No. or year of volume/issue: 58 4
• Volume: 58
• Issue: 4
• Pages: 147-155
• ISSN (Periodical Title): PISSN : 04708105
• Degree grantor/type: 鹿児島大学
• Date Granted: 2018-09-28
• Dissertation Number: 甲総研第462号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Text Language Code: eng
• Subject Heading: acromegaly; surgical cure; Cortina criteria; new consensus criteria; metabolic parameters
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; The criteria for surgical cure of acromegaly have become more stringent during the past decades and a change from Cortina to new consensus criteria has recently been proposed. However, the superiority of the new consensus over Cortina criteria with respect to postoperative metabolic parameters remains to be ascertained. We retrospectively assessed metabolic parameters, the body habitus, and other health-related parameters of 48 patients with surgically controlled acromegaly who met the Cortina criteria [normalized insulin-like growth factor-1 (IGF-1) level and nadir growth hormone (GH) level <1.0 ng/ml during postoperative oral glucose tolerance test]. The 48 patients were divided into two groups. Group A (n = 33) met the new consensus criteria (normalized IGF-1 and nadir GH level <0.4 ng/ml). Group B (n = 15) met Cortina criteria, but their nadir GH ranged from 0.4 to 1.0 ng/ml. In both groups, the level of triglyceride and homeostasis model assessment-insulin resistance (HOMA-IR) was significantly decreased 1 year after the operation (P < 0.05). High-density lipoprotein cholesterol showed a significant increase only in group B (P = 0.02). However, the two groups did not differ with respect to the postoperative improvement rate of these parameters and the other health-related parameters including body mass index, blood pressure, anterior pituitary function, and self-estimated quality of life scale. In conclusion, our findings show that with respect to changes in metabolic parameters and the body habitus assessed 1 year after surgery, the stricter consensus criteria seemed not to be superior to Cortina criteria.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): © 2018 by The Japan Neurosurgical Society
• Related Material: URI; https://www.jstage.jst.go.jp/browse/nmc/-char/en
• Related Material (DOI): 10.2176/nmc.oa.2017-0215
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ

Table of Contents

Result_Yonenaga_Masanori_isk_462_2018 other

Comments_Yonenaga_Masanori_isk_462_2018 other

Diss_米永_理法_ISK462_2018（出版社版） fulltext

Abstract_米永_理法_4513810260_2018 abstract