ホスホリルコリン舌下ならびに経鼻免疫に対する粘膜および全身免疫応答

• Material Type: 博士論文
• Title: ホスホリルコリン舌下ならびに経鼻免疫に対する粘膜および全身免疫応答
• Author/Editor: 間世田, 佳子
• Author Heading: 間世田, 佳子 マセダ, ヨシコ
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2018
• Publication Date (W3CDTF): 2018
• Alternative Title: Mucosal and systemic immune response to sublingual or intranasal immunization with phasphorylcholine
• Periodical title: Auris Nasus Larynx
• No. or year of volume/issue: 45 2
• Volume: 45
• Issue: 2
• Pages: 273-280
• Degree grantor/type: 鹿児島大学
• Date Granted: 2019-02-26
• Dissertation Number: 乙総論第34号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Text Language Code: eng
• Subject Heading: Phosphorylcholine; Sublingual; Intranasal; Streptococcus pneumoniae; Non-typeable Haemophilus influenzae; Immunoglobulin E
• Target Audience: 一般
• Note (General): 博士論文全文, 最終試験結果の要旨, 論文審査の要旨, 博士論文要旨; Objective: Phosphorylcholine (PC) is a structural component of a wide variety of pathogens including Streptococcus pneumoniae and Haemophilus influenzae. Here, the immune response in mice to PC immunization via the sublingual (SL) route versus the intranasal (IN) route was investigated in terms of efficacy and safety. Methods: BALB/c mice were immunized with PC-keyhole limpet hemocyanin (KLH) plus cholera toxin (CT) or CT alone via the IN or SL route. The immune response generated was studied in terms of PC-specific antibody titers, interferon (IFN)-g and interleukin (IL)-4 production by CD4+ T cells, and cross-reactivity of PC-specific immunoglobulin (Ig)-A antibodies in nasal washes against S. pneumoniae and non-typeable H. influenzae. Results: SL and IN immunization with PC-KLH plus CT resulted in a marked increase in the levels of PC-specific, mucosal IgA and serum IgM, IgG, and IgA antibodies. Additionally, SL immunization elicited significantly higher levels of PC-specific IgG2a subclass antibodies and IFNg in serum. On the other hand, IN immunization with CT alone remarkably increased the total IgE level in serum compared with SL and IN immunization with PC-KLH plus CT. PC-specific IgA antibodies in nasal wash samples reacted to most strains of S. pneumoniae and non-typeable H. influenzae. Conclusion: SL immunization is as effective as IN immunization to induce PC-specific immune responses and more effective than IN immunization to reduce the production of IgE and to prevent the sensitization to allergen causing type I allergy.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): © 2017 Elsevier B.V. All rights reserved.
• Related Material: URI; https://www.sciencedirect.com/journal/auris-nasus-larynx
• Related Material (DOI): 10.1016/j.anl.2017.04.009
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ

Table of Contents

Result_Maseda_Yoshiko_isk_34_2019 other

Comments_Maseda_Yoshiko_isk_34_2019 other

Diss_間世田_佳子_ISKr34_2018 fulltext

Abstract_間世田_佳子_TO _2018 abstract