小児・青年期におけるQT 短縮スクリーニングの暫定基準値

Material type: 博士論文

Author: 櫨木, 大祐

Publisher: THE JAPANESE CIRCULATION SOCIETY

Date granted: 2019-03-19

Material Format: Digital

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Degree grantor and degree: 鹿児島大学,博士(医学)

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Note (General)：: 出版タイプ： VoR博士論文本文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨Background: While the prevalence of short QT syndrome (SQTS) in children and adolescents is low, early det...

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Material Type: 博士論文
Title: 小児・青年期におけるQT 短縮スクリーニングの暫定基準値
Author/Editor: 櫨木, 大祐
Author Heading: 櫨木, 大祐ハゼキ, ダイスケ
Publication, Distribution, etc.: THE JAPANESE CIRCULATION SOCIETY
Publication Date: 2018
Publication Date (W3CDTF): 2018
Alternative Title: Tentative Screening Criteria for Short QT Interval in Children and Adolescents.
Periodical title: Circulation Journal
No. or year of volume/issue: 82 10
Volume: 82
Issue: 10
Degree Grantor: 鹿児島大学
Date Granted: 2019-03-19
Dissertation Number: 甲総研第492号
Degree Type: 博士(医学)
Text Language Code: eng
Subject Heading: Adolescent
Children
Screening
Short QT interval
Target Audience: 一般
Note (General): 出版タイプ： VoR
博士論文本文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨
Background: While the prevalence of short QT syndrome (SQTS) in children and adolescents is low, early detection is important because SQTS can cause life-threatening arrhythmia. The aim of this study was to determine the tentative screening criteria for short QT interval in children and adolescents. Methods and Results: A total of 75,040 digitally stored electrocardiograms (ECG) of participants in a school-based ECG screening program were obtained between 2009 and 2013 in Kagoshima, Japan. ECG with a corrected QT interval (QTc) below the 10th percentile for each grade and sex were selected: 2,581 first graders (M/F, 1,296/1,285); 2,792 7th graders (M/F, 1,400/1,392); and 2018 10th graders (M/F, 979/1,039). Three consecutive QT/RR intervals were manually measured and corrected using Bazett's formula. The prevalence of SQTS was estimated at 1/30,000–1/10,000, which was set compared with the prevalence of long QT syndrome, then the screening points of the prevalence of short QT interval were assumed to be between 1/5,000 and 1/2,000 to exclude the possibility of false negative. We obtained the following tentative criteria based on frequency distribution charts: 325, 315 and 305 ms for male 1st, 7th and 10th graders, respectively; and 320 ms for female 1st, 7th, and 10th graders. Conclusions: For primary SQTS screening of children and adolescents, the QTc values for short QT interval should be adapted according to grade and sex.
Format (IMT): application/pdf
Source: Diss_櫨木_大祐_ISK492_2018 （fulltext）
https://ir.kagoshima-u.ac.jp/record/14627/files/Diss_%E6%AB%A8%E6%9C%A8_%E5%A4%A7%E7%A5%90_ISK492_2018.pdf
Access Restrictions: インターネット公開
Related Material: Circulation Journal
https://www.jstage.jst.go.jp/browse/circj/-char/en
Related Material (DOI): 10.1253/circj.CJ-18-0213
https://doi.org/10.1253/circj.CJ-18-0213
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ