日本におけるシャルコーマリートゥース病2F及び遺伝性運動ニューロパチー2Bの臨床的ならびに遺伝学的特徴

• Material Type: 博士論文
• Title: 日本におけるシャルコーマリートゥース病2F及び遺伝性運動ニューロパチー2Bの臨床的ならびに遺伝学的特徴
• Author/Editor: 田邊, 肇
• Author Heading: 田邊, 肇 タナベ, ハジメ
• Publication, Distribution, etc.: Wiley
• Publication Date: 2018
• Publication Date (W3CDTF): 2018
• Alternative Title: Clinical and genetic features of Charcot–Marie–Tooth disease 2F and hereditary motor neuropathy 2B in Japan
• Periodical title: Journal of the Peripheral Nervous System
• No. or year of volume/issue: 23 1
• Volume: 23
• Issue: 1
• Pages: 40-48
• Degree grantor/type: 鹿児島大学
• Date Granted: 2019-03-19
• Dissertation Number: 甲総研第494号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Text Language Code: eng
• Subject Heading: Charcot–Marie–Tooth disease 2F; distal hereditary motor neuropathy 2B; next-generation sequencing; male predominance; abnormal glucose metabolism
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Mutations in small heat shock protein beta-1 (HspB1) have been linked to Charcot–Marie–Tooth (CMT) disease type 2F and distal hereditary motor neuropathy type 2B. Only four cases with HSPB1 mutations have been reported to date in Japan. In this study between April 2007 and October 2014, we conducted gene panel sequencing in a case series of 1,030 patients with inherited peripheral neuropathies (IPNs) using DNA microarray, targeted resequencing, and whole-exome sequencing. We identified HSPB1 variants in 1.3 % (13 of 1,030) of the patients with IPNs, who exhibited a male predominance. Based on neurological and electrophysiological findings, seven patients were diagnosed with CMT disease type 2F, whereas the remaining six patients were diagnosed with distal hereditary motor neuropathy type 2B. P39L, R127W, S135C, R140G, K141Q, T151I, and P182A mutations identified in 12 patients were described previously, whereas a novel K123* variant with unknown significance was found in one patient. Diabetes and impaired glucose tolerance were detected in 6 of the 13 patients. Our findings suggest that HSPB1 mutations result in two phenotypes of inherited neuropathies and extend the phenotypic spectrum of HSPB1-related disorders.
• Format (IMT): application/pdf
• Source: Diss_田邊_肇_ISK494_2018 （fulltext）; https://ir.kagoshima-u.ac.jp/record/14629/files/Diss_%E7%94%B0%E9%82%8A_%E8%82%87_ISK494_2018%EF%BC%88%E8%91%97%E8%80%85%E6%9C%80%E7%B5%82%E7%A8%BF%EF%BC%89.pdf
• Access Restrictions: インターネット公開
• Rights (production): © 2018 The Authors. Journal of the Peripheral Nervous System published by Wiley Periodicals, Inc. on behalf of Peripheral Nerve Society.
• Related Material: Journal of the Peripheral Nervous System; https://onlinelibrary.wiley.com/journal/15298027
• Related Material (DOI): 10.1111/jns.12252
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ