敗血症患者の循環ヒストンH3レベルは、凝固障害、多臓器不全、および死亡と関連している : 単一施設観察研究

• Material Type: 博士論文
• Title: 敗血症患者の循環ヒストンH3レベルは、凝固障害、多臓器不全、および死亡と関連している : 単一施設観察研究
• Author/Editor: 横山, 弥生
• Author Heading: 横山, 弥生 ヨコヤマ, ヤヨイ
• Publication, Distribution, etc.: BMC
• Publication Date: 2019
• Publication Date (W3CDTF): 2019
• Alternative Title: Circulating histone H3 levels in septic patients are associated with coagulopathy, multiple organ failure, and death: a single-center observational study
• Periodical title: Thrombosis Journal
• No. or year of volume/issue: 17
• Volume: 17
• Degree grantor/type: 鹿児島大学
• Date Granted: 2019-03-25
• Dissertation Number: 甲総研第498号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Text Language Code: eng
• Subject Heading: Histone; Sepsis; Coagulopathy; Organ failure
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Background: Nuclear histone proteins are released into the extracellular space, and act as major mediators of coagulopathy and remote organ failure in septic animals. However, the circulating histone levels in septic patients have not been precisely quantified. Methods: Using a novel enzyme-linked immunosorbent assay for histone H3 detection, we measured the serum histone H3 levels in 85 patients admitted to the intensive care unit because of infectious diseases. We then evaluated the associations of circulating histone H3 levels with organ failure, coagulopathy, and mortality. Results: Circulating histone H3 levels were significantly higher in patients with coagulopathy, and were positively correlated with numbers of organ failures. Circulating histone H3 levels were also associated with fatal outcome. Receiver-operating characteristic analyses revealed that the predictive performance of circulating histone H3 levels for mortality was higher than that of conventional inflammatory markers, including white blood cell count, C-reactive protein, and cell-free DNA. Conclusions: Circulating histone H3 levels are associated with coagulopathy, multiple organ failure, and death in patients requiring intensive care because of infectious diseases.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Related Material: URI; https://thrombosisjournal.biomedcentral.com/
• Related Material (DOI): 10.1186/s12959-018-0190-4
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ

Table of Contents

Result_Yokoyama_Yayoi_isk_498 other

Comments_Yokoyama_Yayoi_isk_498 other

Diss_横山_弥生_ISK498_2018 fulltext

Abstract_横山_弥生_4514810371_2018 abstract