胃癌におけるHHLA2の発現と予後の関連

• Material Type: 博士論文
• Title: 胃癌におけるHHLA2の発現と予後の関連
• Author/Editor: 下之薗, 将貴
• Author Heading: 下之薗, 将貴 シモノソノ, マサタカ
• Publication, Distribution, etc.: Oncotarget
• Publication Date: 2018
• Publication Date (W3CDTF): 2018
• Alternative Title: The association of human endogenous retrovirus-H long terminal repeat-associating protein 2 (HHLA2) expression with gastric cancer prognosis
• Periodical title: Oncotarget
• No. or year of volume/issue: 9 31
• Volume: 9
• Issue: 31
• Pages: 22069-22078
• Degree grantor/type: 鹿児島大学
• Date Granted: 2019-03-19
• Dissertation Number: 甲総研第508号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Text Language Code: eng
• Subject Heading: human endogenous retrovirus-H long terminal repeat-associating protein 2; quantitative reverse transcription-polymerasechain reaction; peripheral blood; prognostic marker; gastric cancer
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Currently, immune checkpoint blockade against members of the B7/CD28 family is being used as a new molecular-targeted therapy, in patients with unresectable advanced or recurrent gastric cancer. Although human endogenous retrovirus-H long terminal repeat-associating protein 2 (HHLA2) is a novel molecule of the B7/CD28 family, the clinical impact of its expression remains uncertain in gastric cancer. Consequently, we examined HHLA2 expression in blood specimens from patients with gastric cancer, and investigated the relationship between its expression and clinicopathological factors to assess its potential power as a prognostic blood predictor. Untreated peripheral blood specimens were obtained from 111 patients with gastric cancer and 20 healthy volunteers. HHLA2 mRNA expression levels were determined using quantitative RT-PCR assay. Blood specimens obtained from patients with gastric cancer had significantly lower copies of HHLA2 mRNA than those obtained from healthy volunteers (P < 0.0001). Furthermore, HHLA2 expression was significantly correlated with the depth of tumor invasion (P = 0.0331), distant metastasis (P < 0.0001), and stage of disease (P = 0.0032). The 5-year survival rate was significantly higher in patients with high HHLA2 expression compared with the patients with low expression (P = 0.0001). These findings demonstrate that assessment of HHLA2 expression levels in the blood could be utilized to predict tumor aggressiveness in patients with gastric cancer.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Related Material: URI; http://www.oncotarget.com/
• Related Material (DOI): 10.18632/oncotarget.25179
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ

Table of Contents

Result_Shimonosono_Masataka_isk_508 other

Comments_Shimonosono_Masataka_isk_508 other

Diss_下之薗_将貴_ISK508_2018 fulltext

Abstract_下之薗_将貴_4516810147_2018 abstract