有棘赤血球舞踏病モデルマウスは、精子中片部のミトコンドリア鞘の超微細構造異常を原因とした精子の運動障害により、雄性不妊を呈する

• Material Type: 博士論文
• Title: 有棘赤血球舞踏病モデルマウスは、精子中片部のミトコンドリア鞘の超微細構造異常を原因とした精子の運動障害により、雄性不妊を呈する
• Author/Editor: 永田, 青海
• Author Heading: 永田, 青海 ナガタ, オオミ
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2018
• Publication Date (W3CDTF): 2018
• Alternative Title: Mouse model of chorea-acanthocytosis exhibits male infertility caused by impaired sperm motility as a result of ultrastructural morphological abnormalities in the mitochondrial sheath in the sperm midpiece
• Periodical title: Biochemical and Biophysical Research Communications
• No. or year of volume/issue: 503 2
• Volume: 503
• Issue: 2
• Pages: 915-920
• Degree grantor/type: 鹿児島大学
• Date Granted: 2019-05-31
• Dissertation Number: 甲総研第510号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Text Language Code: eng
• Subject Heading: Chorea-acanthocytosis; ChAc-model mouse; male infertility; asthenozoospermia; Vps13a; chorein; mitochondria
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Chorea-acanthocytosis (ChAc) is an autosomal recessive hereditary disease characterized by neurodegeneration in the striatum and acanthocytosis caused by loss-of-function mutations in the Vacuolar Protein Sorting 13 Homolog A (VPS13A) gene, which encodes chorein. We previously produced a ChAc-model mouse with a homozygous deletion of exons 60–61 in Vps13a, which corresponded to the human disease mutation. We found that male ChAc-model mice exhibited complete infertility as a result of severely diminished sperm motility. Immunocytochemical study revealed that chorein-like immunoreactivity is abundant only in the midpiece, mitochondria-rich region, of the sperm of wild type mice. They showed no significant differences from wild types in terms of the adenosine 5′-triphosphate (ATP) concentration of their sperm, sperm count, or sexual activity. Electron microscopy revealed abnormal ultrastructural morphology of the mitochondria in the midpiece of sperm from ChAc-model mice. These results suggest that chorein is essential in mouse sperm for the maintenance of ultrastructural mitochondrial morphology and sperm motility.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): © 2018 Elsevier Inc. All rights reserved.
• Related Material: URI; https://www.sciencedirect.com/journal/biochemical-and-biophysical-research-communications
• Related Material (DOI): 10.1016/j.bbrc.2018.06.096
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ

Table of Contents

Result_Nagata_Omi_isk_510 other

Comments_Nagata_Omi_isk_510 other

Diss_永田_青海_ISK510_2019 fulltext

Abstract_永田_青海_4513800129_2018 abstract