胃癌の転移リンパ節における、EMT変化が与える臨床的意義

• Material Type: 博士論文
• Title: 胃癌の転移リンパ節における、EMT変化が与える臨床的意義
• Author/Editor: 大久保, 啓史
• Author Heading: 大久保, 啓史 オオクボ, ケイシ
• Publication, Distribution, etc.: Springer
• Publication Date: 2017
• Publication Date (W3CDTF): 2017
• Alternative Title: Clinical significance of altering epithelial-mesenchymal transition (EMT) in metastatic lymph nodes of gastric cancer
• Periodical title: Gastric Cancer
• No. or year of volume/issue: 20 5
• Volume: 20
• Issue: 5
• Pages: 802-810
• Degree grantor/type: 鹿児島大学
• Date Granted: 2019-08-28
• Dissertation Number: 甲総研第517号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Text Language Code: eng
• Subject Heading: Epithelial-mesenchymal transition (EMT); Gastric cancer; Metastatic lymph nodes; Snail switch
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Background: E-cadherin, N-cadherin, and Snail are epithelial-mesenchymal transition (EMT)-inducible genes. Previous studies demonstrated that the expression of EMT markers in the primary tumor sites of gastric cancer correlates with tumor progression and prognosis. However, the clinical significance of the expression of these EMT markers in metastatic lymph nodes remains unclear. In the present study, we investigated the expression of these EMT markers in the primary tumor sites and metastatic lymph nodes. Methods: Immunohistochemistry was used to investigate the expression of E-cadherin, N-cadherin, and Snail in 89 primary tumors and 511 metastatic lymph nodes obtained from patients with gastric cancer. Results: The weak expression of E-cadherin in tumors and lymph nodes increased with more lymph node metastasis and in more undifferentiated tumors. The strong expression of N-cadherin in lymph nodes correlated with more lymph nodes metastasis, an advanced stage and poor prognosis. The weak expression of Snail in tumors correlated with lymphatic invasion. The strong expression of Snail in lymph nodes correlated with more lymph node metastasis and an advanced stage. The strong expression of Snail in tumors and its weak expression in lymph nodes correlated with more lymph node metastasis, an advanced stage, and poor prognosis. Conclusions: The expression of N-cadherin in metastatic lymph nodes is useful for predicting the prognosis of patients with gastric cancer. The Snail switch, namely, the positive-to-negative conversion of the Snail status, between primary tumors and lymph node metastasis may be important for confirming EMT and mesenchymal-to-epithelial transition (MET).
• Format (IMT): application/pdf
• Source: Diss_大久保_啓史_ISK517_2019 （fulltext）; https://ir.kagoshima-u.ac.jp/record/14899/files/Diss_%E5%A4%A7%E4%B9%85%E4%BF%9D_%E5%95%93%E5%8F%B2_ISK517_2019.pdf
• Access Restrictions: インターネット公開
• Rights (production): Springer
• Related Material: The final publication is available at link.springer.com; https://doi.org/10.1007/s10120-017-0705-x
• Related Material (DOI): 10.1007/s10120-017-0705-x
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ