肺高血圧症における右室壁応力と血漿BNP値の相関

• Material Type: 博士論文
• Title: 肺高血圧症における右室壁応力と血漿BNP値の相関
• Author/Editor: 内山, 奈美
• Author Heading: 内山, 奈美 ウチヤマ, ナミ
• Publication, Distribution, etc.: Japanese Circulation Society
• Publication Date: 2019
• Publication Date (W3CDTF): 2019
• Alternative Title: Correlation of Right Ventricular Wall Stress with Plasma B-Type Natriuretic Peptide Levels in Patients with Pulmonary Hypertension
• Periodical title: Circulation Journal
• No. or year of volume/issue: 83 6
• Volume: 83
• Issue: 6
• Pages: 1278-1285
• Degree grantor/type: 鹿児島大学
• Date Granted: 2019-09-17
• Dissertation Number: 甲総研第518号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Text Language Code: eng
• Subject Heading: B-type natriuretic peptide; Pulmonary hypertension; Right ventricular wall stress
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Background: This study was designed to investigate the relationship between right ventricular wall stress (RVWS) and plasma B-type natriuretic peptide (BNP) levels in patients with pulmonary hypertension (PH). Methods and Results: The 57 consecutive PH patients and 8 control subjects were enrolled. Right heart catheterization (RHC), echocardiography, and BNP measurements were performed, and RVWS and left ventricular wall stress (LVWS) were calculated with the formula based on Laplace's law. Systolic RVWS and end-diastolic RVWS were higher in PH patients compared with controls (systolic RVWS: 77±41 vs. 17±5 kdynes/cm2 (P<0.0001), end-diastolic RVWS: 15±12 vs. 8±2 kdynes/cm2 (P<0.0005)). Univariate analyses showed that logBNP at baseline correlated with systolic RVWS (r=0.58, P<0.0001) and end-diastolic RVWS (r=0.61, P<0.0001). We performed multivariate regression analysis and determined that end-diastolic RVWS was an independent determinant of logBNP in patients with PH. In addition, change in plasma BNP levels after treatment correlated with change in systolic RVWS (r=0.70, P<0.0001) and change in end-diastolic RVWS (r=0.68, P<0.0001). Conclusions: Both systolic and end-diastolic RVWS were elevated in patients with PH, and correlated with the symptoms of PH. End-diastolic RVWS was an independent determinant of plasma BNP levels in PH patients.
• Format (IMT): application/pdf
• Source: Diss_内山_奈美_ISK518_2019 （fulltext）; https://ir.kagoshima-u.ac.jp/record/14900/files/Diss_%E5%86%85%E5%B1%B1_%E5%A5%88%E7%BE%8E_ISK518_2019.pdf
• Access Restrictions: インターネット公開
• Rights (production): All rights are reserved to the Japanese Circulation Society.
• Related Material: Circulation Journal; https://www.jstage.jst.go.jp/browse/circj/-char/en
• Related Material (DOI): 10.1253/circj.CJ-18-1155
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ