胃癌におけるGremlin1の発現と、臨床病理学的意義

• Material Type: 博士論文
• Title: 胃癌におけるGremlin1の発現と、臨床病理学的意義
• Author/Editor: 山崎, 洋一
• Author Heading: 山崎, 洋一 ヤマサキ, ヨウイチ
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2018
• Publication Date (W3CDTF): 2018
• Alternative Title: Expression of gremlin1 in gastric cancer and its clinical significance
• Periodical title: Medical Oncology
• No. or year of volume/issue: 35 30
• Volume: 35
• Issue: 30
• Degree grantor/type: 鹿児島大学
• Date Granted: 2019-11-20
• Dissertation Number: 甲総研第524号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Text Language Code: eng
• Subject Heading: gremlin1; gastric cancer; immunohistochemistry; survival
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; As an antagonist of bone morphogenetic proteins (BMPs) 2, 4 and 7, gremlin1 plays a role in regulating organogenesis, tissue differentiation and angiogenesis. However, there is little information regarding gremlin1 in gastrointestinal cancer. We attempted to clarify how gremlin1 expression affects the clinical features and biological properties of gastric cancer. A total of 232 gastric cancer patients who received R0 gastrectomy at Kagoshima University Hospital were enrolled. Gremlin1 expression in gastric cancer was detected by immunohistochemical and western blotting methods. Correlations between clinicopathological parameters and gremlin1 expression were analyzed. Gremlin1 was identified in the cytoplasm and nucleus of all gastric cancer cell lines and some regions of surgical specimens of gastric cancer. One hundred and seventeen of the 232 patients (50.4%) were classified as gremlin1-positive based on gremlin 1 expression. Gremlin1 positivity was correlated with shallower tumor depth, smaller tumor size, less nodal involvement and vessel invasion (p<0.05). The 5-year survival rate of the gremlin1-positive group was 81%, which was significantly higher than the gremlin1-negative group (p<0.01). Multivariate analysis revealed that gremlin1 was not selected as an independent prognostic marker. Gremlin1 expression in gastric cancer may be a useful prognostic marker that is involved with the BMP signaling pathway. Furthermore, gremlin1 may have clinical use as a diagnostic and treatment tool. Yamasaki, Y., Ishigami, S., Arigami, T. et al. Expression of gremlin1 in gastric cancer and its clinical significance Med Oncol (2018) 35: 30. https://doi.org/10.1007/s12032-017-1073-4
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1007/s12032-017-1073-4
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ

Table of Contents

Result_Yamasaki_Yoichi_isk_524 other

Comments_Yamasaki_Yoichi_isk_524_2019 other

Diss_山﨑_洋一_ISK524_2019 fulltext

Abstract_山﨑_洋一_4513810241_2019 abstract