高周波カテーテルアブレーション治療を施行した心房細動患者における可溶性トロンポモジュリンと循環miRNAの動態

• Material Type: 博士論文
• Title: 高周波カテーテルアブレーション治療を施行した心房細動患者における可溶性トロンポモジュリンと循環miRNAの動態
• Author/Editor: 波野, 史典
• Author Heading: 波野, 史典 ナミノ, フミノリ
• Publication, Distribution, etc.: SAGE
• Publication Date: 2019
• Publication Date (W3CDTF): 2019
• Alternative Title: Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patlents with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation
• Periodical title: Clinical and Applied Thrombosis/Hemostasis
• No. or year of volume/issue: 25
• Volume: 25
• Degree grantor/type: 鹿児島大学
• Date Granted: 2019-11-20
• Dissertation Number: 甲総研第525号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Text Language Code: eng
• Subject Heading: atrial fibrillation; catheter ablation; soluble thrombomodulin; plasminogen activator inhibitor-1; miRNA; primary miRNA
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Atrial fibrillation (AF) is the most common cardiac arrhythmia in the world and has a high risk of thromboembolism. The most effective approach, catheter ablation, requires evaluation by electrocardiography. The aim of our study was to investigate novel clinical markers that predict restoration of sinus rhythm (SR) after catheter ablation. Seventy-eight consecutive patients with AF underwent catheter ablation and were separated into 2 groups: restored SR and recurrent AF. The levels of 4 blood proteins (serum or plasma) and 3 mature microRNAs (miRNAs) and their primary miRNAs (pri-miRNAs) in serum were measured before and after ablation, and the associations between each parameter were analyzed statistically. Soluble thrombomodulin (s-TM) and plasminogen activator inhibitor-1 (PAI-1) levels increased above baseline after ablation in both the restored SR (s-TM 11.55 [2.92] vs 13.75 [3.38], P < .001; PAI-1 25.74 [15.25] vs 37.79 [19.56], P < .001) and recurrent AF (s-TM 10.28 [2.78] vs 11.67 [3.37], P < .001; PAI-1 26.16 [15.70] vs 40.74 [22.55], P < .001) groups. Levels of C-reactive protein and asymmetric dimethylarginine were not significantly changed. Pri-miR-126 levels significantly decreased after ablation in the recurrent AF group, but the other miRNAs and pri-miRNAs did not. The measurement of s-TM and pri-miR-126 in blood was a useful tool to reflect the condition of AF patients with catheter ablation. Namino F. Yamakuchi M. Iriki Y. Okui H. Ichiki H. Maenosono R. Oketani N. Masamoto I. Miyata M. Horiuchi M. Hashiguchi T. Ohishi M. Maruyama I. Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patlents with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation Clinical and Applied Thrombosis/Hemostasis Volume 25: 1-11 https://doi.org/10.1177/1076029619851570
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1177/1076029619851570
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ

Table of Contents

Result_Namino_Fuminori_isk_525_2019 other

Comments_Namino_Fuminori_isk_525_2019 other

Diss_波野_史典_ISK525_2019 fulltext

Abstract_波野_史典_4514810193_2019 abstract