エストロゲン依存性疾患、外科的去勢および抗がん剤の肌年齢に及ぼす影響(日本人女性での検討)

• Material Type: 博士論文
• Title: エストロゲン依存性疾患、外科的去勢および抗がん剤の肌年齢に及ぼす影響(日本人女性での検討)
• Author/Editor: 劉, 水策
• Author Heading: 劉, 水策
• Publication, Distribution, etc.: 鹿児島大学
• Publication Date: 2019
• Publication Date (W3CDTF): 2019
• Alternative Title: Influences of estrogen-dependent diseases, premature oophorectomy and anti-cancer chemotherapy on skin age in Japanese women
• Periodical title: 鹿児島大学医学雑誌
• No. or year of volume/issue: 71 1-3
• Volume: 71
• Issue: 1-3
• Pages: 23-34
• Degree grantor/type: 鹿児島大学
• Date Granted: 2019-11-20
• Dissertation Number: 甲総研第527号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Text Language Code: eng
• Subject Heading: anti-cancer chemotherapy; estrogen-dependent diseases; premature oophorectomy; skin age; skin health conditions
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Aim: The purpose of the present study was to investigate the influences of estrogen-dependent diseases, premature oophorectomy and anti-cancer chemotherapy on skin age in Japanese women. Materials and methods: A total of 68 Japanese women were recruited between July 2016 and May 2018 at the Department of Obstetrics and Gynecology, Kagoshima University Hospital. This study included three subjects. Subject 1: A total of 57 premenopausal women were divided into two groups: those with estrogen-dependent diseases (n=19) and estrogen-independent diseases (n=38). Subject 2: A total of 26 premenopausal women were divided into two groups: those with premature oophorectomy (n=15) and ovarian preservation (n=11) during gynecological surgery. Subject 3: A total of 11 postmenopausal women who had received oophorectomy during their cancer operations were divided into two groups: those with postoperative anti-cancer chemotherapy (n=6) and those without chemotherapy (control, n=5). Facial skin parameters including skin age, relative skin age (i.e., skin age minus chronological age) and skin health conditions were assessed using a bioelectrical impedance analysis device. Results: 1) Relative skin age was significantly younger in women with estrogen-dependent diseases than in those with estrogenindependent diseases (-1.0 ± 1.4 vs. 2.5 ± 0.6 years, respectively, p<0.01). 2) Longitudinal changes in relative skin age at 6 months postoperatively in the oophorectomy group had progressed significantly compared with the ovarian preservation group (3.5 ± 1.4 vs. - 0.2 ± 0.8 years, respectively, p<0.05). 3) Longitudinal changes in relative skin age at 12 months after chemotherapy in postmenopausal women who received 6 courses of postoperative anti-cancer chemotherapy had progressed significantly compared with control (10.5 ± 3.3 vs. -3.8 ± 3.4 years, respectively, p<0.05). The ratio of young skin conditions was also significantly decreased after chemotherapy (from 5/6 to 1/6, respectively, p<0.05). Conclusions: Women with estrogen-dependent diseases maintain a younger facial skin age than those with estrogen-independent diseases. However, skin aging is accelerated by premature oophorectomy and markedly accelerated by anti-cancer chemotherapy. LIU Shuice, ORITA Yuji, IWAMOTO Ichiro, SAKIHAMA Mika, TOGAMI Shinichi, OUCHI Tsutomu, KOBAYASHI Hiroaki Influences of estrogen-dependent diseases, premature oophorectomy and anti-cancer chemotherapy on skin age in Japanese women Medical journal of Kagoshima University 71(1-3) 23-34, (2019)
• Format (IMT): application/pdf
• Source: Diss_劉_水策_ISK527_2019 （fulltext）; https://ir.kagoshima-u.ac.jp/record/14945/files/Diss_%E5%8A%89_%E6%B0%B4%E7%AD%96_ISK527_2019.pdf
• Access Restrictions: インターネット公開
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ