マイクロチップ式血流下自動解析システムを用いて評価した血栓形成に対する血糖コントロールと低血糖の影響 : 探索的観察研究

• Material Type: 博士論文
• Title: マイクロチップ式血流下自動解析システムを用いて評価した血栓形成に対する血糖コントロールと低血糖の影響 : 探索的観察研究
• Author/Editor: 山元, 聖明
• Author Heading: 山元, 聖明 ヤマモト, キヨアキ
• Publication, Distribution, etc.: BMC
• Publication Date: 2019-09-02
• Publication Date (W3CDTF): 2019-09-02
• Alternative Title: Effects of glycemic control and hypoglycemia on Thrombus formation assessed using automated microchip flow chamber system : an exploratory observational study
• Periodical title: Thrombosis Journal
• Degree grantor/type: 鹿児島大学
• Date Granted: 2019-12-18
• Dissertation Number: 甲総研第528号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Text Language Code: eng
• Subject Heading: Glycemic control; Hyperglycemia; Hypoglycemia
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Background: Thrombus formation is an important factor affecting cardiovascular events and venous thromboembolism in type 2 diabetes. However, it is unclear whether glycemic control reduces thrombogenicity. We investigated the effect of short-term glycemic control (STUDY 1) and hypoglycemia (STUDY 2) on thrombus formation using an automated microchip flow chamber system. Methods: For STUDY 1, we recruited 10 patients with type 2 diabetes. Before and after 2 weeks of treatment, blood glucose was analyzed with a continuous glucose monitoring system, and thrombogenicity was analyzed with an automated microchip flow chamber system. For STUDY 2, we recruited 10 subjects without diabetes who underwent an insulin tolerance test. We evaluated the change in thrombogenic potential with hypoglycemia. Results: STUDY1: The mean blood glucose level reduced from 10.1 ± 2.6 to 6.9 ± 0.97mM (P < 0.01). T10, an indicator of thrombogenicity, significantly attenuated after glycemic control (338 ± 65 vs. 425 ± 117 s, P < 0.05). The attenuation in T10 was significantly correlated with changes in mean blood glucose level after treatment (r = − 0.718, P < 0.05). STUDY 2: Platelet function was enhanced with decreasing blood glucose; increased platelet function was strongly correlated with an increase in epinephrine. Conclusions: We demonstrated attenuation in thrombogenicity with short-term comprehensive diabetes care and enhancement in thrombogenicity with hypoglycemia, using a new flow chamber system. Kiyoaki Yamamoto, Takashi Ito, Tomoka Nagasato, Atsushi Shinnakasu, Mihoko Kurano, Aiko Arimura, Hiroshi Arimura, Hiroshi Hashiguchi, Takahisa Deguchi, Ikuro Maruyama and Yoshihiko Nishio Effects of glycemic control and hypoglycemia on Thrombus formation assessed using automated microchip flow chamber system: an exploratory observational study Thrombosis Journal (2019) doi: https://doi.org/10.1186/s12959-019-0206-8
• Format (IMT): application/pdf
• Source: Diss_山元_聖明_ISK000_2019 （fulltext）; https://ir.kagoshima-u.ac.jp/record/14958/files/Diss_%E5%B1%B1%E5%85%83_%E8%81%96%E6%98%8E_ISK000_2019.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1186/s12959-019-0206-8
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ