末梢単核白血球の血小板活性化因子受容体(PAFR)遺伝子発現変化と糖尿病性腎症の進展との関連

• Material Type: 博士論文
• Title: 末梢単核白血球の血小板活性化因子受容体(PAFR)遺伝子発現変化と糖尿病性腎症の進展との関連
• Author/Editor: Ghavidel Darestani, Sahar
• Author Heading: Ghavidel Darestani, Sahar
• Publication, Distribution, etc.: Springer
• Publication Date: 2020
• Publication Date (W3CDTF): 2020
• Alternative Title: Association between changes in the mRNA expression of platelet-activating factor receptor in peripheral blood mononuclear cells and progression of diabetic nephropathy
• Periodical title: Diabetology International
• No. or year of volume/issue: 11
• Volume: 11
• Pages: 11-18
• Degree Grantor: 鹿児島大学
• Date Granted: 2020-01-28
• Dissertation Number: 甲総研第534号
• Degree Type: 博士(医学)
• Text Language Code: eng
• Target Audience: 一般
• Note (General): 出版タイプ： VoR; 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Introduction: Several studies have recently pointed out the role of many inflammatory mediators in the progression of diabetes complications. We had previously demonstrated that mRNA expression of platelet activating factor receptor (PAFR) in peripheral blood mononuclear cells (PBMCs) was associated with urinary albumin to creatinine ratio (ACR) and forearm flow-mediated dilatation in patients with type 2 diabetes. In an attempt to elucidate this association, patients were followed up for 1 year. Materials and Methods: We recruited 95 patients from the hospital outpatient clinic, among whom 86 were followed up for 1 year (normoalbuminuria: 40 patients, microalbuminuria: 25 patients, macroalbuminuria: 21 patients). We then measured their baseline and 12 month characteristics and collected blood samples to extract PBMCs and measure gene expressions. Results: Despite higher mRNA expression of PAFR in PBMCs among patients with macroalbuminuria, the rise in its value was not associated with biomarkers of nephropathy, while baseline values were not associated with progression of nephropathy. Moreover, changes in mRNA expression of PAFR were correlated with changes in ACR in all patients (r = 0.225, p = 0.037) and estimated glomerular filtration rate in patients with macroalbuminuria (r = −0.438, p = 0.047) during the follow-up period. Conclusion: Our findings indicate that even though no causal relationship exists between diabetic nephropathy and elevated expression of PAFR in PBMCs, their close association; signifies the presence of another common mechanism that could induce both events. Given these findings, the PAF/PAFR interaction could clarify corresponding mechanisms involved in diabetic complications. Sahar Ghavidel Darestani, Mihoko Kurano, Atsushi Shinnakasu, Kiyoaki Yamamoto, Yukari Dochi, Kayo Uemura, Yuko Ikeda, Aiko Arimura, Hiroshi Arimura, Akira Kikuchi, Hiroshi Hashiguchi, Takahisa Deguchi, Yoshihiko Nishio Association between changes in the mRNA expression of platelet activating factor receptor in peripheral blood mononuclear cells and progression of diabetic nephropathy Diabetology International, 11, 11–18(2020) This is a post-peer-review, pre-copyedit version of an article published in Diabetology International. The final authenticated version is available online at: https://doi.org/10.1007/s13340-019-00394-w
• Format (IMT): application/pdf
• Source: Diss_Sahar Ghavidel_Darestani_ISK534_2019 （fulltext）; https://ir.kagoshima-u.ac.jp/record/14995/files/Diss_Sahar%20Ghavidel_Darestani_ISK534_2019.pdf
• Access Restrictions: インターネット公開
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ