切除可能な胃癌に対する深達度と腫瘍径から測定される Primary Tumor Scoreの臨床的意義

Material type: 博士論文

Author: 原口, 尚士

Publisher: Oncotarget

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Material Format: Digital

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Name of awarding university/degree: 鹿児島大学,博士(医学),Doctor of Philosophy in Medical Science

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Note (General)：: 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨Although postoperative management of gastric cancer is determined by pathological stage based on the tumor-node-meta...

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Material Type: 博士論文
Title: 切除可能な胃癌に対する深達度と腫瘍径から測定される Primary Tumor Scoreの臨床的意義
Author/Editor: 原口, 尚士
Author Heading: 原口, 尚士ハラグチ, ナオト
Publication, Distribution, etc.: Oncotarget
Alternative Title: Clinical significance of primary tumor score determined by tumor depth and size in patients with resectable gastric cancer
Degree grantor/type: 鹿児島大学
Date Granted: 2020-03-12
Dissertation Number: 甲総研第538号
Degree Type: 博士(医学)
Doctor of Philosophy in Medical Science
Text Language Code: eng
Subject Heading: primary tumor score
tumor size
depth of tumor invasion
prognostic factor
gastric cancer
Target Audience: 一般
Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨
Although postoperative management of gastric cancer is determined by pathological stage based on the tumor-node-metastasis classification, predicting disease recurrence and prognosis in patients undergoing gastrectomy is clinically difficult. We investigated the depth of tumor invasion and tumor size in resected specimens from patients with gastric cancer and assessed the clinical utility of primary tumor score (PTS) calculated by tumor depth and size as a prognostic marker. We classified 247 patients with gastric cancer into three groups based on cut-off values for deeper tumor invasion (pT2–T4) and larger tumor size (≥ 45 mm) as a PTS of 2 (both abnormalities), 1 (one abnormality), or 0 (neither abnormality). PTS correlated significantly with lymph node metastasis, lymphovascular invasion, and stage (P < 0.0001 each). Survival differences among groups based on PTS were significant (P < 0.0001). Multivariate analysis identified PTS alone as an independent prognostic factor (P = 0.0363). PTS derived from primary tumor information alone is a potentially useful marker for predicting tumor progression and prognosis in postoperative patients with gastric cancer. Naoto Haraguchi, Takaaki Arigami, Yoshikazu Uenosono, Shigehiro Yanagita, Yasuto Uchikado, Shinichiro Mori, Hiroshi Kurahara, Yuko Kijima, Akihiro Nakajo, Kosei Maemura, Sumiya Ishigami and Shoji Natsugoe Clinical significance of primary tumor score determined by tumor depth and size in patients with resectable gastric cancer Oncotarget. 2018; 9:8512-8520 https://doi.org/10.18632/oncotarget.23953
Format (IMT): application/pdf
Source: Diss_原口_尚士_ISK538_2019 （fulltext）
https://ir.kagoshima-u.ac.jp/record/15168/files/Diss_%E5%8E%9F%E5%8F%A3_%E5%B0%9A%E5%A3%AB_ISK538_2019.pdf
Access Restrictions: インターネット公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ