切除可能な胃癌に対する深達度と腫瘍径から測定される Primary Tumor Scoreの臨床的意義

• Material Type: 博士論文
• Title: 切除可能な胃癌に対する深達度と腫瘍径から測定される Primary Tumor Scoreの臨床的意義
• Author/Editor: 原口, 尚士
• Author Heading: 原口, 尚士 ハラグチ, ナオト
• Publication, Distribution, etc.: Oncotarget
• Alternative Title: Clinical significance of primary tumor score determined by tumor depth and size in patients with resectable gastric cancer
• Degree grantor/type: 鹿児島大学
• Date Granted: 2020-03-12
• Dissertation Number: 甲総研第538号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Text Language Code: eng
• Subject Heading: primary tumor score; tumor size; depth of tumor invasion; prognostic factor; gastric cancer
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Although postoperative management of gastric cancer is determined by pathological stage based on the tumor-node-metastasis classification, predicting disease recurrence and prognosis in patients undergoing gastrectomy is clinically difficult. We investigated the depth of tumor invasion and tumor size in resected specimens from patients with gastric cancer and assessed the clinical utility of primary tumor score (PTS) calculated by tumor depth and size as a prognostic marker. We classified 247 patients with gastric cancer into three groups based on cut-off values for deeper tumor invasion (pT2–T4) and larger tumor size (≥ 45 mm) as a PTS of 2 (both abnormalities), 1 (one abnormality), or 0 (neither abnormality). PTS correlated significantly with lymph node metastasis, lymphovascular invasion, and stage (P < 0.0001 each). Survival differences among groups based on PTS were significant (P < 0.0001). Multivariate analysis identified PTS alone as an independent prognostic factor (P = 0.0363). PTS derived from primary tumor information alone is a potentially useful marker for predicting tumor progression and prognosis in postoperative patients with gastric cancer. Naoto Haraguchi, Takaaki Arigami, Yoshikazu Uenosono, Shigehiro Yanagita, Yasuto Uchikado, Shinichiro Mori, Hiroshi Kurahara, Yuko Kijima, Akihiro Nakajo, Kosei Maemura, Sumiya Ishigami and Shoji Natsugoe Clinical significance of primary tumor score determined by tumor depth and size in patients with resectable gastric cancer Oncotarget. 2018; 9:8512-8520 https://doi.org/10.18632/oncotarget.23953
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ

Table of Contents

Result_Haraguchi_Naoto_isk_538 other

Comments_Haraguchi_Naoto_isk_538 other

Diss_原口_尚士_ISK538_2019 fulltext

Abstract_原口_尚士_4509810343_2019 abstract