胃癌において Programmed death-ligand 1 は腫瘍悪牲度や予後の予測のための有用な血液マーカーである

Material type: 博士論文

Author: 天辰, 仁彦

Publisher: Wiley

Publication date: -

Material Format: Digital

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Name of awarding university/degree: 鹿児島大学,博士(医学),Doctor of Philosophy in Medical Science

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Note (General)：: 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨Immune checkpoint inhibitor therapy has been clinically introduced for several malignancies, and its effectiveness h...

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Material Type: 博士論文
Title: 胃癌において Programmed death-ligand 1 は腫瘍悪牲度や予後の予測のための有用な血液マーカーである
Author/Editor: 天辰, 仁彦
Author Heading: 天辰, 仁彦アマタツ, マサヒコ
Publication, Distribution, etc.: Wiley
Alternative Title: Programmed death-ligand 1 is a promising blood maker for predicting tumor progression and prognosis in patients with gastric cancer
Degree grantor/type: 鹿児島大学
Date Granted: 2020-03-12
Dissertation Number: 甲総研第540号
Degree Type: 博士(医学)
Doctor of Philosophy in Medical Science
Text Language Code: eng
Subject Heading: gastric cancer
liquid biopsy
peripheral blood
prognosis
programmed death-ligand 1
Target Audience: 一般
Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨
Immune checkpoint inhibitor therapy has been clinically introduced for several malignancies, and its effectiveness has been confirmed by clinical trials. In particular, programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) are widely known as important immune checkpoint molecules associated with the mechanisms of immune escape by malignant tumor cells. In addition, liquid biopsy of blood specimens has the clinical benefit of providing a simple, repeatable sampling tool. Non-invasive liquid biopsy has recently been spotlighted as a promising approach to predicting tumor progression and prognosis. This study assessed the clinical significance of PD-L1 mRNA expression in blood specimens obtained from patients with gastric cancer. Peripheral blood specimens were collected before treatment from 124 patients with gastric cancer. The PD-L1 mRNA expression was evaluated by quantitative RT-PCR. Programmed death-ligand 1 mRNA expression was significantly higher in patients with advanced gastric cancer than in patients with early gastric cancer (P = .002). Moreover, PD-L1 expression correlated significantly with depth of tumor invasion, distant metastasis, and stage (P = .001, P < .001, and P < .001, respectively). Patients with high PD-L1 expression showed significantly poorer prognosis than those with low PD-L1 expression (P < .0001). Multivariate analysis indicated PD-L1 expression as an independent prognostic factor. Expression of PD-L1 in peripheral blood may offer an immunological predictor of tumor progression and disease outcome in patients with gastric cancer. Masahiko Amatatsu, Takaaki Arigami, Yoshikazu Uenosono, Shigehiro Yanagita, Yasuto Uchikado, Yuko Kijima, Hiroshi Kurahara, Yoshiaki Kita, Shinichiro Mori, Ken Sasaki, Itaru Omoto, Kosei Maemura, Sumiya Ishigami, Shoji Natsugoe Programmed death-ligand 1 is a promising blood marker for predicting tumor progression and prognosis in patients with gastric cancer Cancer Science 2018 109(3) 814-820 https://doi.org/10.1111/cas.13508
Format (IMT): application/pdf
Source: Diss_天辰_仁彦_ISK540_2019 （fulltext）
https://ir.kagoshima-u.ac.jp/record/15170/files/Diss_%E5%A4%A9%E8%BE%B0_%E4%BB%81%E5%BD%A6_ISK540_2019.pdf
Access Restrictions: インターネット公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ