オウバクの Streptococcus mutans に対する抗菌効果

Material type: 博士論文

Author: 辻井, 利弥

Publisher: The Societies and John Wiley & Sons

Publication date: -

Material Format: Digital

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Name of awarding university/degree: 鹿児島大学,博士(歯学),Doctor of Philosophy in Dental Science

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Note (General)：: 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨Streptococcus mutans is a major cause of tooth decay due to its promotion of biofilm formation and acid production. ...

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Material Type: 博士論文
Title: オウバクの Streptococcus mutans に対する抗菌効果
Author/Editor: 辻井, 利弥
Author Heading: 辻井, 利弥ツジイ, トシヤ
Publication, Distribution, etc.: The Societies and John Wiley & Sons
Alternative Title: Antibacterial　activity of phellodendron bark against Streptococcus mutans
Degree grantor/type: 鹿児島大学
Date Granted: 2020-08-20
Dissertation Number: 甲総研第569号
Degree Type: 博士(歯学)
Doctor of Philosophy in Dental Science
Text Language Code: eng
Subject Heading: antibacterial agents and chemotherapy
bacteriology
pathogenesis
Streptococcus mutans
Target Audience: 一般
Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨
Streptococcus mutans is a major cause of tooth decay due to its promotion of biofilm formation and acid production. Several plant extracts have been reported to have multiple biological activities such as anti‐inflammation and antibacterial effects. This study investigated the antibacterial activity of three plant extracts, phellodendron bark (PB), yucca, and black ginger, and found that PB had a stronger effect than the other extracts. Then, the minimum inhibitory concentration (MIC) of PB against 100 S. mutans strains was investigated. The MIC range of PB was 9.8–312.5 µg/mL. PB suppressed the growth kinetics of S. mutans in a dose‐dependent manner, even at sub‐MICs of PB. Then, we investigated the effect of PB on S. mutans virulence. The PB suppressed biofilm formation at high concentrations, although PB did not affect the expression of glucosyltransferase genes. Additionally, PB suppressed the decrease in pH from adding an excess of glucose. The expression of genes responsible for acid production was increased by the addition of excess glucose without PB, whereas their expression levels were not increased in the presence of 1× and 2× MIC of PB. Although PB showed a bacteriostatic effect on planktonic S. mutans cells, it was found that more than 2× MIC of PB showed a partial bactericidal effect on biofilm cells. In conclusion, PB not only showed antibacterial activity against S. mutans but also decreased the cariogenic activity in S. mutans. Toshiya Tsujii, Miki Kawada‐Matsuo, Hirono Migita, Kouji Ohta, Yuichi Oogai, Youichi Yamasaki, Hitoshi Komatsuzawa Antibacterial activity of phellodendron bark against Streptococcus mutans Microbiology and Immunology 64(6) p.424-434 2020 https://doi.org/10.1111/1348-0421.12787
Format (IMT): application/pdf
Source: Diss_辻井_利弥_ISK569_2020 （fulltext）
https://ir.kagoshima-u.ac.jp/record/15471/files/Diss_%E8%BE%BB%E4%BA%95_%E5%88%A9%E5%BC%A5_ISK569_2020.pdf
Access Restrictions: インターネット公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ