肝細胞癌におけるCD68、CD163ならびに葉酸レセプターβ陽性マクロファージの予後的意義

• Material Type: 博士論文
• Title: 肝細胞癌におけるCD68、CD163ならびに葉酸レセプターβ陽性マクロファージの予後的意義
• Author/Editor: 南, 幸次
• Publication, Distribution, etc.: 鹿児島大学
• Alternative Title: Prognostic Significance of CD68, CD163 and Folate receptor beta Positive Macrophage in Hepatocellular Carcinoma
• Degree grantor/type: 鹿児島大学
• Dissertation Number: 甲総研第571号
• Degree Type: 博士(医学)
• Subject Heading: hepatocellular carcinoma; cluster of differentiation 68; cluster of differentiation 163; folate receptor β; macrophage
• Target Audience: 一般
• Note (General): 出版タイプ： VoR; 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Cluster of differentiation (CD)68 may be used as a pan‑macrophage or M1 marker, whereas CD163 may be used as an M2 marker. Furthermore, folate receptor (FR)β exhibits an M2‑like functional profile. In the present study, CD68 and CD163 were used to evaluate and classify tumor‑associated macrophages (TAMs). The expression of CD68, CD163 and FRβ by TAMs in hepatocellular carcinoma (HCC) Tissues was investigated. Samples from 105 patients with HCC were evaluated using immunohistochemistry. The results revealed that CD68 and CD163 overexpression was associated with a worse prognosis. The number of CD68 positive cells observed was significantly higher in patients with stage IV cancer. Furthermore, an increase in CD68 positive cells was observed in patients with median tumor size ≥3.5 cm and in patients with poorly differentiated HCC. The number of CD163 positive cells was also significantly increased in patients with median tumor size ≥3.5 cm and in those with poorly differentiated HCC. A low CD163/68 ratio was correlated with a worse outcome. The ratio was significantly lower in patients with stage IV cancer, patients with des‑gamma‑carboxy prothrombin abnormalities, patients with blood vessel infiltration and patients with intrahepatic metastasis. The number of FRβ positive cells was not correlated with clinicopathological features. The results of the present study indicate that overexpression of CD68 and CD163 may be associated with a worse patient outcome. The evaluation of CD68 and CD163 positive cells in a cancer microenvironment is controversial. TAMs are not simply cells with single markers or restricted M1 or M2 phenotypes; they are more diverse and heterogeneous. Further studies are required to determine the cross‑interaction between diverse TAMs and the tumor microenvironment. Koji Minami, Kiyokazu Hiwatashi, Shinichi Ueno, Masahiko Sakoda, Satoshi Iino, Hiroshi Okumura, Motoyuki Hashiguchi, Yota Kawasaki, Hiroshi Kurahara, Yuko Mataki, Kosei Maemura, Hiroyuki Shinchi, Shoji Natsugoe Prognostic significance of CD68, CD163 and Folate receptor‑β positive macrophages in hepatocellular carcinoma Experimental and Therapeutic Medicine 15(5) 4465-4476 2018 https://doi.org/10.3892/etm.2018.5959
• Format (IMT): application/pdf
• Source: Diss_南_幸次_ISK571_2020 （fulltext）; https://ir.kagoshima-u.ac.jp/record/15480/files/Diss_%E5%8D%97_%E5%B9%B8%E6%AC%A1_ISK571_2020.pdf
• Access Restrictions: インターネット公開
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ