アルツハイマー病モデルマウスにおける認知機能、海馬Aβ沈着、神経細胞喪失、神経炎症、酸化ストレスに対する低強度運動バランス運動と協調運動の効果

Material type: 博士論文

Author: 中西, 和毅

Publisher: Elsevier

Publication date: -

Material Format: Digital

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Name of awarding university/degree: 鹿児島大学,博士（保健学）,Doctor of Philosophy in Health Science

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Note (General)：: 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨It is well known that physical exercise reduces the risk of Alzheimer's disease (AD) and age-related cognitive decli...

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Material Type: 博士論文
Title: アルツハイマー病モデルマウスにおける認知機能、海馬Aβ沈着、神経細胞喪失、神経炎症、酸化ストレスに対する低強度運動バランス運動と協調運動の効果
Author/Editor: 中西, 和毅
Author Heading: 中西, 和毅ナカニシ, カズキ
Publication, Distribution, etc.: Elsevier
Alternative Title: Effects of low intensity motor balance and coordination exercise on cognitive functions, hippocampal Aβ deposition, neuronal loss, neuroinflammation, and oxidative stress in a mouse model of Alzheimer’s disease
Degree grantor/type: 鹿児島大学
Date Granted: 2021-03-25
Dissertation Number: 甲保研第24号
Degree Type: 博士（保健学）
Doctor of Philosophy in Health Science
Text Language Code: eng
Subject Heading: SAMP8
Rotarod exercise
Neuroinflammation
M1 phenotype microglia
A1 phenotype astrocyte
Nitric oxide synthase activity
Target Audience: 一般
Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨
It is well known that physical exercise reduces the risk of Alzheimer's disease (AD) and age-related cognitive decline. However, its mechanisms are still not fully understood. This study aimed to investigate the effect of aging and rotarod exercise (Ex) on cognitive function and AD pathogenesis in the hippocampus using senescence-accelerated mice prone 8 (SAMP8). Cognitive functions clearly declined at 9-months of age. Amyloid-beta (Aβ) deposition, neuronal loss, and glia activation-induced neuroinflammation increased with aging. The rotarod Ex prevented the decline of cognitive functions corresponding to the suppression of Aβ deposition, neuroinflammation, neuronal loss, inducible nitric oxide synthase (NOS) activities, and neuronal NOS activities. In addition, the rotarod Ex suppressed proinflammatory M1 phenotype microglia and A1 phenotype astrocytes. Our findings suggest that low-intensity motor balance and coordination exercise prevented age-related cognitive decline in the early stage of AD progression, possibly through the suppression of hippocampal Aβ deposition, neuronal loss, oxidative stress, and neuroinflammation, including reduced M1 and A1 phenotypes microglia and astrocytes. Kazuki Nakanishi, Harutoshi Sakakima, Kosuke Norimatsu, Shotaro Otsuka, Seiya Takada, Akira Tani, Kiyoshi Kikuchi Effects of low intensity motor balance and coordination exercise on cognitive functions, hippocampal Aβ deposition, neuronal loss, neuroinflammation, and oxidative stress in a mouse model of Alzheimer’s disease Experimental Neurology 337, 2021 113590 https://doi.org/10.1016/j.expneurol.2020.113590
Format (IMT): application/pdf
Source: Diss_中西_和毅_4718700041_2020 （fulltext）
https://ir.kagoshima-u.ac.jp/record/15751/files/Diss_%E4%B8%AD%E8%A5%BF_%E5%92%8C%E6%AF%85_4718700041_2020.pdf
Access Restrictions: インターネット公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ