淡明腎細胞癌において、miRNA-1274aを抑制することによりBMPR1Bの発現が回復し、癌細胞のアポトーシスが誘導される

Material type: 博士論文

Author: 米澤, 智一

Publisher: Spandidos Publications

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Material Format: Digital

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Name of awarding university/degree: 鹿児島大学,博士(医学),Doctor of Philosophy in Medical Science

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Note (General)：: 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨Our previous studies of the microRNA (miRNA) expression signature in clear cell renal cell carcinoma (ccRCC) indicat...

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Material Type: 博士論文
Title: 淡明腎細胞癌において、miRNA-1274aを抑制することによりBMPR1Bの発現が回復し、癌細胞のアポトーシスが誘導される
Author/Editor: 米澤, 智一
Author Heading: 米澤, 智一ヨネザワ, トモカズ
Publication, Distribution, etc.: Spandidos Publications
Alternative Title: Downregulation of microRNA-1274a induces cell apoptosis through regulation of BMPR1B in clear cell renal cell carcinoma
Degree grantor/type: 鹿児島大学
Date Granted: 2021-05-17
Dissertation Number: 甲総研第605号
Degree Type: 博士(医学)
Doctor of Philosophy in Medical Science
Text Language Code: eng
Subject Heading: microRNA
miR-1274a
renal cell carcinoma
apoptosis
upregulated miRNA
Target Audience: 一般
Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨
Our previous studies of the microRNA (miRNA) expression signature in clear cell renal cell carcinoma (ccRCC) indicated that miRNA-1274a (miR-1274a) was significantly upregulated in clinical specimens, suggesting that miR-1274a may act as an oncogenic miRNA in ccRCC. The aim of this study was to investigate the functional roles of miR-1274a and identify downstream tumor-suppressive targets regulated by miR‑1274a in ccRCC cells. Functional studies of miR-1274a were carried out by anti-miRNA to investigate cell proliferation and apoptosis using the A498, ACHN and Caki1 ccRCC cell lines. Suppression of miR-1274a significantly inhibited cancer cell proliferation and induced apoptosis in the ccRCC cells. Gene expression data combined with in silico analysis and luciferase reporter assays demonstrated that bone morphogenetic protein receptor type 1B (BMPR1B) was directly regulated by miR-1274a. Moreover, TCGA database as well as immunohistochemistry demonstrated low expression of BMPR1B in ccRCC clinical specimens compared to that in normal kidney tissues. We conclude that loss of oncogenic miR-1274a reduced cancer cell proliferation and induced apoptosis in ccRCC through targeting BMPR1B. Our data revealing molecular pathways and a target gene regulated by oncogenic miR-1274a provide new insight into the potential mechanisms of ccRCC oncogenesis. Hirofumi Yoshino, Tomokazu Yonezawa, Masaya Yonemori, Kazutaka Miyamoto, Takashi Sakaguchi, Satoru Sugita, Youichi Osako, Shuichi Tatarano, Masayuki Nakagawa, Hideki Enokida Downregulation of microRNA-1274a induces cell apoptosis through regulation of BMPR1B in clear cell renal cell carcinoma Oncology Reports 2018 39(1) p.173-181 https://doi.org/10.3892/or.2017.6098
Format (IMT): application/pdf
Source: Diss_米澤_智一_ISK605_2021 （fulltext）
https://ir.kagoshima-u.ac.jp/record/15870/files/Diss_%E7%B1%B3%E6%BE%A4_%E6%99%BA%E4%B8%80_ISK605_2021.pdf
Access Restrictions: インターネット公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ