粉末経鼻投与システムを用いたカニクイザルにおけるOVA経鼻投与後の全身及び粘膜免疫の誘導評価

• Material Type: 博士論文
• Title: 粉末経鼻投与システムを用いたカニクイザルにおけるOVA経鼻投与後の全身及び粘膜免疫の誘導評価
• Author/Editor: 鳥飼, 祐介
• Author Heading: 鳥飼, 祐介 トリカイ, ユウスケ
• Publication, Distribution, etc.: Elsevier
• Alternative Title: Evaluation of Systemic and Mucosal Immune Responses Induced by a Nasal Powder Delivery System in Conjunction with an OVA Antigen in Cynomolgus Monkeys
• Degree grantor/type: 鹿児島大学
• Date Granted: 2021-07-15
• Dissertation Number: 甲総研第613号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Text Language Code: eng
• Subject Heading: Controlled delivery; Controlled release; Drug delivery system; Formulation; Immunogenicity; Mucoadhesive; Mucosal vaccination; Powder technology; Nasal drug delivery; Vaccine
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; An immune response for a nasal ovalbumin (OVA) powder formulation with an applied nasal delivery platform technology, consisting of a powdery nasal carrier and a device, was evaluated in monkeys with similar upper respiratory tracts and immune systems to those of humans, in order to assess the applicability to a vaccine antigen. Nasal distribution and retention studies using a 3D nasal cavity model and manganese-enhanced MRI were conducted by administering nasal dye and manganese powder formulations with the applied technology. Systemic and mucosal immune responses for the nasal OVA powder formulation were evaluated by determining serum IgG and nasal wash IgA antibody titers. The nasal dye and manganese powder formulations showed wider distribution and longer retention time than did a nasal liquid formulation. The nasal OVA powder formulation also showed comparable and higher antigen-specific IgG antibody titer to an injection and nasal liquid formulation, respectively. Furthermore, antigen-specific IgA antibody response was detected only for the nasal OVA powder formulation. The present study suggests that the technology, originally designed for drug absorption, is promising for nasal vaccines, enabling both a mucosal immunity response as the first line of defense and systemic immunity response as a second line of defense against infection. Yusuke Torikai, Yuji Sasaki, Keita Sasaki, Akifumi Kyunob, Shunji Haruta, Akihide Tanimoto Evaluation of Systemic and Mucosal Immune Responses Induced by a Nasal Powder Delivery System in Conjunction with an OVA Antigen in Cynomolgus Monkeys Journal of Pharmaceutical Sciences 110(5), 2021, P.2038-2046 https://doi.org/10.1016/j.xphs.2020.11.023
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ

Table of Contents

Result_torikai_yuusuke_isk_613 other

Comments_torikai_yuusuke _isk_613 other

Diss_鳥飼_祐介_ISK613_2021 fulltext

Abstract_鳥飼_祐介_4513810321_2020 abstract