大腸がん患者は口腔・腸内細菌叢に共通して4種の特異な菌種を有する : メタゲノム解析による健常者との比較

• Material Type: 博士論文
• Title: 大腸がん患者は口腔・腸内細菌叢に共通して4種の特異な菌種を有する : メタゲノム解析による健常者との比較
• Author/Editor: 内野, 祥徳
• Author Heading: 内野, 祥徳 ウチノ, ヨシノリ
• Publication, Distribution, etc.: MDPI
• Alternative Title: Colorectal Cancer Patients Have Four Specific Bacterial Species in Oral and Gut Microbiota in Common : A Metagenomic Comparison with Healthy Subjects
• Degree grantor/type: 鹿児島大学
• Date Granted: 2021-12-15
• Dissertation Number: 甲総研第626号
• Degree Type: 博士(歯学); Doctor of Philosophy in Dental Science
• Text Language Code: eng
• Subject Heading: microbiota; oral bacteria; colorectal cancer; Peptostreptococcus; Streptococcus; Solobacterium spp.
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Oral microbiota is reportedly associated with gut microbiota and influences colorectal cancer (CRC) progression; however, the details remain unclear. This study aimed to evaluate the role of oral microbiota in CRC progression. Fifty-two patients with CRC and 51 healthy controls were included. Saliva and stool samples were collected, and microbiota were evaluated using 16S rRNA analysis and next-generation sequencing. Comparative analysis was performed on both groups. Linear discriminant analysis effect size (LEfSe) revealed the presence of indigenous oral bacteria, such as Peptostreptococcus, Streptococcus, and Solobacterium spp., at a significantly higher relative abundance in saliva and stool samples of CRC patients compared with controls. Next, CRC patients were divided into early stage (Stage I, II; n = 26; 50%) and advanced stage (Stage III, IV; n = 26; 50%) disease. LEfSe revealed that S. moorei was present at a significantly higher relative abundance in the advanced-stage group compared with the early-stage group, again consistent for both saliva and stool samples. Among bacterial species with significantly higher relative abundance in CRC patients, P. stomatis, S. anginosus, S. koreensis, and S. moorei originated from the oral cavity, suggesting indigenous oral bacteria may have promoted initiation of CRC carcinogenesis. Furthermore, S. moorei may influence CRC progression. Yoshinori Uchino, Yuichi Goto, Yusuke Konishi, Kan Tanabe, Hiroko Toda, Masumi Wada, Yoshiaki Kita, Mahiro Beppu, Shinichiro Mori, Hiroshi Hijioka, Takao Otsuka, Shoji Natsugoe, Eiji Hara, Tsuyoshi Sugiura Colorectal Cancer Patients Have Four Specific Bacterial Species in Oral and Gut Microbiota in Common : A Metagenomic Comparison with Healthy Subjects Cancers 2021, 13(13), 3332 https://doi.org/10.3390/cancers13133332
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ

Table of Contents

Result_Uchino_Yoshinori_isk_626 other

Comments_Uchino_Yoshinori_isk_626 other

Diss_内野_祥徳_ISK626_2021 fulltext

Abstract_内野_祥徳_4517810071_2021 abstract