HGFはマウスモデルにおいてメチルグリオキサール誘導の腹膜の炎症および線維化を改善する

Material type: 博士論文

Author: 吉嶺, 陽仁

Publisher: Springer Nature

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Name of awarding university/degree: 鹿児島大学,博士(医学),Doctor of Philosophy in Medical Science

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Note (General)：: 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨Background: Peritoneal dialysis (PD) is essential for patients with end-stage renal disease. Peritoneal fibrosis (PF...

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Material Type: 博士論文
Title: HGFはマウスモデルにおいてメチルグリオキサール誘導の腹膜の炎症および線維化を改善する
Author/Editor: 吉嶺, 陽仁
Author Heading: 吉嶺, 陽仁ヨシミネ, ハルヒト
Publication, Distribution, etc.: Springer Nature
Alternative Title: Hepatocyte growth factor ameliorates methylglyoxal-induced peritoneal inflammation and fibrosis in mouse model
Degree grantor/type: 鹿児島大学
Date Granted: 2022-03-25
Dissertation Number: 甲総研第645号
Degree Type: 博士(医学)
Doctor of Philosophy in Medical Science
Text Language Code: eng
Subject Heading: Hepatocyte growth factor
Peritoneal fibrosis
Methylglyoxal
Peritoneal dialysis
Target Audience: 一般
Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨
Background: Peritoneal dialysis (PD) is essential for patients with end-stage renal disease. Peritoneal fibrosis (PF) is a complex inflammatory, fibrogenic process. No effective treatments are available to prevent these processes. Hepatocyte growth factor (HGF) possesses anti-inflammatory and anti-fibrotic properties. The aim of this study was to analyze whether HGF suppresses MGO-induced peritoneal inflammation and fibrosis in a mouse model. Methods: PF was induced by intraperitoneal (IP) injections of MGO for 14 days. C57/BL/6 mice were divided into three groups: Sham group (only vehicle); Sham + MGO group (PF induced by MGO); and HGF + MGO group (PF mice treated with recombinant human-HGF). PF was assessed from tissue samples by Masson’s trichrome staining. Inflammation and fibrosis-associated factors were assessed by immunohistochemistry and quantitative real-time PCR. Results: MGO-injected mice showed significant thickening of the submesothelial compact zone with PF. Treatment with HGF significantly reduced PM thickness and suppressed the expression of collagen I and III and α-SMA. Expression of profibrotic and proinflammatory cytokines (TGF-β, TNF-α, IL-1β) was reduced by HGF treatment. The number of macrophages, and M1 and M2 macrophage-related markers, such as CD86, CD206, and CD163, was reduced in HGF + MGO mice. Conclusion: HGF attenuates MGO-induced PF in mice. Furthermore, HGF treatment reduces myofibroblast and macrophage infiltration, and attenuates the upregulated expression of proinflammatory and profibrotic genes in peritoneal tissues. HGF might be an effective approach to prevent the development of PF in patients undergoing PD. Haruhito Yoshimine, Shiroh Tanoue, Yutaro Ibi, Masato Minami, Mai Nakahara, Koki Tokunaga, Shuji Kanmura & Akio Ido Hepatocyte growth factor ameliorates methylglyoxal-induced peritoneal inflammation and fibrosis in mouse model Clinical and Experimental Nephrology 25, 935–943 (2021) This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s10157-021-02067-y
Format (IMT): application/pdf
Source: Diss_吉嶺_陽仁_ISK645_2021 （fulltext）
https://ir.kagoshima-u.ac.jp/record/16098/files/Diss_%E5%90%89%E5%B6%BA_%E9%99%BD%E4%BB%81_ISK645_2021.pdf
Access Restrictions: インターネット公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ