PCP4/PEPl9及びHER2は唾液腺粘表皮癌における新規の予後判定マーカーである

Material type: 博士論文

Author: 東, 翔太朗

Publisher: MDPI

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Material Format: Digital

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Name of awarding university/degree: 鹿児島大学,博士(歯学),Doctor of Philosophy in Dental Science

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Note (General)：: 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨Mucoepidermoid carcinoma (MEC) is one of the most common malignant salivary gland carcinomas, but no effective treat...

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Material Type: 博士論文
Title: PCP4/PEPl9及びHER2は唾液腺粘表皮癌における新規の予後判定マーカーである
Author/Editor: 東, 翔太朗
Author Heading: 東, 翔太朗ヒガシ, ショウタロウ
Publication, Distribution, etc.: MDPI
Alternative Title: PCP4/PEP19 and HER2 Are Novel Prognostic Markers in Mucoepidermoid Carcinoma of the Salivary Gland
Degree grantor/type: 鹿児島大学
Date Granted: 2022-03-11
Dissertation Number: 甲総研第653号
Degree Type: 博士(歯学)
Doctor of Philosophy in Dental Science
Text Language Code: eng
Subject Heading: mucoepidermoid carcinoma
Purkinje cell protein 4/peptide 19
human epidermal growth factor 2
prognosis
salivary gland
Target Audience: 一般
Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨
Mucoepidermoid carcinoma (MEC) is one of the most common malignant salivary gland carcinomas, but no effective treatment strategy has been established other than surgical resection. Purkinje cell protein (PCP) 4/peptide (PEP) 19 is a calmodulin-binding antiapoptotic peptide that is expressed and inhibits apoptosis in human breast cancer cells. Human epidermal growth factor receptor 2 (HER2) is an epidermal growth factor that has been implicated in the pathogenesis of many carcinomas, particularly breast and gastric carcinomas. In the present study, we performed immunohistochemical analyses of samples from 73 patients who underwent surgical resection for MEC of the salivary gland using antibodies against PCP4/PEP19 and HER2. PCP4/PEP19 expression was related to better prognosis, while HER2 expression was associated with worse prognosis. Patients that were PCP4/PEP19-positive and HER2-negative showed similar outcomes to PCP4/PEP19 and HER2 alone. Therefore, PCP4/PEP19 and HER2 are predicted to play important roles in the pathogenesis and progression of MEC. Takuya Yoshimura, Shotaro Higashi, Sohsuke Yamada, Hirotsugu Noguchi, Mitsuharu Nomoto, Hajime Suzuki, Takayuki Ishida, Hirotaka Takayama, Yuka Hirano, Masaru Yamashita, Akihide Tanimoto and Norifumi Nakamura PCP4/PEP19 and HER2 Are Novel Prognostic Markers in Mucoepidermoid Carcinoma of the Salivary Gland Cancers 2022, 14(1), 54 https://doi.org/10.3390/cancers14010054
Format (IMT): application/pdf
Source: Diss_東_翔太朗_ISK653_2021 （fulltext）
https://ir.kagoshima-u.ac.jp/record/16106/files/Diss_%E6%9D%B1_%E7%BF%94%E5%A4%AA%E6%9C%97_ISK653_2021.pdf
Access Restrictions: インターネット公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ