エナメル上皮腫細胞と骨芽細胞の細胞間シグナル伝達について

Material type: 博士論文

Author: ハイラニ, エリサ

Publisher: Elsevier

Publication date: -

Material Format: Digital

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Name of awarding university/degree: 鹿児島大学,博士(歯学),Doctor of Philosophy in Dental Science

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Note (General)：: 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨Ameloblastoma is an odontogenic tumor located in the bone jaw with clinical characteristics of extensive bone resorp...

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Material Type: 博士論文
Title: エナメル上皮腫細胞と骨芽細胞の細胞間シグナル伝達について
Author/Editor: ハイラニ, エリサ
Author Heading: ハイラニ, エリサ
Publication, Distribution, etc.: Elsevier
Alternative Title: Intercellular Siganling between Ameloblastoma and Osteoblasts
Degree grantor/type: 鹿児島大学
Date Granted: 2022-04-20
Dissertation Number: 甲総研第657号
Degree Type: 博士(歯学)
Doctor of Philosophy in Dental Science
Text Language Code: eng
Subject Heading: Ameloblastoma
AM-3
Osteoblast
Tumor-bone microenvironment
Cytokine
Intercellular communication
Target Audience: 一般
Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨
Ameloblastoma is an odontogenic tumor located in the bone jaw with clinical characteristics of extensive bone resorption. It is a locally invasive tumor with a high recurrence rate despite adequate surgical removal. In bone disease, tumors and other cells including osteoblasts, osteoclasts, and osteocytes in the bone microenvironment contribute to the pathogenesis of tumor growth. However, the effect of osteoblasts on ameloblastoma cells is not well-understood, and there has been limited research on interactions between them. This study investigated interactions between ameloblastoma cells and osteoblasts using a human ameloblastoma cell line (AM-3 ameloblastoma cells) and a murine pre-osteoblast cell line (MC3T3-E1 cells). We treated each cell type with the conditioned medium by the other cell type. We analyzed the effect on cytokine production by MC3T3-E1 cells and the production of MMPs by AM-3 cells. Treatment with AM-3-conditioned medium induced inflammatory cytokine production of IL-6, MCP-1, and RANTES from MC3T3-E1 cells. The use of an IL-1 receptor antagonist suppressed the production of these inflammatory cytokines by MC3T3-E1 cells stimulated with AM-3-conditioned medium. The MC3T3-E1-conditioned medium triggered the expression of MMP-2 from AM-3 cells. Furthermore, we have shown that the proliferation and migration activity of AM-3 cells were accelerated by MC3T3-E1 conditioned media. In conclusion, these intercellular signalings between ameloblastoma cells and osteoblasts may play multiple roles in the pathogenesis of ameloblastoma. Elissa Chairani, Takao Fuchigami, Hirofumi Koyama, Yusuke Ono, Mikio Iijima, Michiko Kishida, Toshiro Kibe, Norifumi Nakamura, Shosei Kishida Intercellular signaling between ameloblastoma and osteoblasts Biochemistry and Biophysics Reports 30 (2022) 101233 https://doi.org/10.1016/j.bbrep.2022.101233
Format (IMT): application/pdf
Source: Diss_エリサ_ハイラニ_ISK657_2022 （fulltext）
https://ir.kagoshima-u.ac.jp/record/16111/files/Diss_%E3%82%A8%E3%83%AA%E3%82%B5_%E3%83%8F%E3%82%A4%E3%83%A9%E3%83%8B_ISK657_2022.pdf
Access Restrictions: インターネット公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ